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Documentos Principais

358M-1

Sigma-Aldrich

MUM1 (MRQ-8) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

MRQ-8, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (358M-14)
vial of 0.5 mL concentrate (358M-15)
bottle of 1.0 mL predilute (358M-17)
vial of 1.0 mL concentrate (358M-16)
bottle of 7.0 mL predilute (358M-18)

fabricante/nome comercial

Cell Marque

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1κ

controle

B-cell chronic lymphocytic leukemia (B-CLL), plasma cell myeloma, tonsil

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic, nuclear

Informações sobre genes

human ... PWWP3A(84939)

Descrição geral

MUM1 (multiple myeloma oncogene-1)/IRF4 (interferon regulatory factor 4) is a 50 kDa protein encoded by MUM1 gene, and a member of the interferon regulatory factor family of transcription factors. MUM1/IRF4 is expressed in the nuclei of plasma cells and a small percentage of germinal center (GC) B-cells located in the “light zone”. This antibody stains MUM1 protein, which is expressed in a subset of B-cells in the light zone of the germinal center, plasma cells, activated T-cells, and a wide spectrum of related hematolymphoid neoplasms derived from these cells. Therefore, this antibody is useful for the subclassiffication of lymphoid malignancies and an excellent marker for Reed-Sternberg cells of classic Hodgkin disease in combination with anti-CD30.

Qualidade


IVD

IVD

IVD

RUO

Ligação

MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Visite a Biblioteca de Documentos

G Gaidano et al.
Leukemia, 14(4), 563-566 (2000-04-14)
In recent times, the field of B cell lymphoma histogenesis has progressed rapidly due to the increasing availability of histogenetic markers. Genotypic markers of B cell histogenesis are represented by mutations of IgV and BCL-6 genes, which are somatically acquired
Y Natkunam et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(7), 686-694 (2001-07-17)
The gene encoding MUM1 was characterized as a possible translocation partner in chromosomal abnormalities involving a significant number of multiple myelomas. The overexpression of the MUM1 protein as a result of translocation t(6;14) (p25;q32) identified MUM1 as a putative regulatory
B Falini et al.
Blood, 95(6), 2084-2092 (2000-03-09)
A new monoclonal antibody (MUM1p) was used to study the cell/tissue expression of human MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma-associated t(6;14) (p25;q32). MUM1 was expressed in the nuclei and cytoplasm of plasma cells and
Antonino Carbone et al.
British journal of haematology, 117(2), 366-372 (2002-04-26)
Biological and clinical studies have shown that Hodgkin's disease (HD) can be divided into two major categories, termed nodular lymphocyte predominance HD (NLP HD) and classic HD (CHD). Within CHD four subtypes have been distinguished: nodular sclerosis, mixed cellularity, lymphocyte
Mathewos Tessema et al.
PloS one, 7(4), e34850-e34850 (2012-04-13)
Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n =

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