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Key Documents

30020

Sigma-Aldrich

D-Cycloserine

Sinônimo(s):

R-4-Amino-3-isoxazolidinone, (R)-4-Amino-3-isoxazolidone, 4-Amino-3-isoxazolidinone

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About This Item

Fórmula empírica (Notação de Hill):
C3H6N2O2
Número CAS:
Peso molecular:
102.09
Beilstein:
80798
Número CE:
Número MDL:
Código UNSPSC:
51102829
ID de substância PubChem:
NACRES:
NA.85

fonte biológica

synthetic

Nível de qualidade

forma

powder

potência

≥900 μg per mg

cor

white to off-white

pf

147 °C (dec.) (lit.)

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modo de ação

cell wall synthesis | interferes

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

chave InChI

DYDCUQKUCUHJBH-UWTATZPHSA-N

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Descrição geral

Chemical structure: amino acid derivatives

Aplicação

D-Cycloserine acts as inhibitor of various enzymes.

Ações bioquímicas/fisiológicas

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.
Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic.
Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.
Mode of Resistance: D-Ala transport interference.

Embalagem

1g, 5g, 25g

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Keep in a dry place.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


Certificados de análise (COA)

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Marta Portero-Tresserra et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 24(11), 1798-1807 (2014-12-03)
Previous research has demonstrated that systemic D-cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate receptor (NMDAR), enhances memory processes in different learning paradigms and attenuates mnemonic deficits produced by diverse pharmacological manipulations. In the present study two experiments were conducted
Stefan G Hofmann et al.
Current psychiatry reports, 17(1), 532-532 (2014-11-22)
Although cognitive behavioral therapy (CBT) is a generally effective treatment for treating anxiety disorders, there is clearly still room for further improvements. Recent advances in neuroscience of extinction learning led to novel clinical strategies to augment exposure-based treatments with d-cycloserine
Simon P Byrne et al.
Depression and anxiety, 32(6), 408-414 (2015-03-17)
For exposure therapy to be successful, it is essential that fear extinction learning extends beyond the treatment setting. D-cycloserine (DCS) may facilitate treatment gains by increasing generalization of extinction learning, however, its effects have not been tested in children. We

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