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282M-9

Sigma-Aldrich

HMB-45 (HMB-45) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

HMB-45, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (282M-94)
vial of 0.5 mL concentrate (282M-95)
bottle of 1.0 mL predilute (282M-97)
vial of 1.0 mL concentrate (282M-96)
bottle of 7.0 mL predilute (282M-98)

fabricante/nome comercial

Cell Marque®

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1κ

controle

melanoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic

Descrição geral

Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigenspresent on immature melanosomes. Anti-HMB45 is useful for identifying amelanoticmelanoma from other neoplastic lesions with similar morphology.

Qualidade


IVD
IVD
IVD
RUO

Ligação

HMB-45 Positive Control Slides, Product No. 282S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificados de análise (COA)

Lot/Batch Number
0000288449
0000288449
1413607A-Z
1413608A-Z

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Helene Nortvig Abrahamsen et al.
Cancer, 100(8), 1683-1691 (2004-04-10)
The optimal technique for sentinel lymph node (SN) assessment in patients with melanoma is controversial. Molecular analysis (reverse transcriptase-polymerase chain reaction) detects significantly greater numbers of SNs with suspected micrometastases (up to 71%) than does routine histopathology (approximately 20%). The
M R Wick et al.
Archives of pathology & laboratory medicine, 112(6), 616-620 (1988-06-01)
The efficacy of two new monoclonal antibodies with cell lineage-restricted reactivity (HMB-45 [melanocytes] and anti-synaptophysin [neuroepithelial cells]) was compared with that of "traditional" antibody panels in the delineation of malignant melanoma (MM) of the sinonasal region, nasopharyngeal carcinoma (NPC), and
L Weiss et al.
The Journal of pathology, 150(3), 195-203 (1986-11-01)
The sequence of events in haematogenous metastasis from colonic carcinoma was analysed, using 1541 necropsy reports from 16 centres. The findings are consistent with the cascade hypothesis that metastases develop in discrete steps, first in the liver, next in the
An assessment of a melanoma-specific antibody (HMB-45) and other immunohistochemical markers of malignant in paraffin-embedded tissue.
AS-Y Leong, et al.
Surgical Pathology, 2, 137-145 (1989)
B L Baisden et al.
The American journal of surgical pathology, 24(8), 1140-1146 (2000-08-10)
Despite the profound therapeutic and prognostic implications of nodal metastases in patients with melanoma, there is no consensus strategy for the optimal detection of metastases in sentinel lymph node biopsies. Traditional microscopic examination may be too crude to detect scattered
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