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16859

Sigma-Aldrich

D-α-Hydroxyglutaric acid disodium salt

≥98.0% (GC)

Sinônimo(s):

(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate

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About This Item

Fórmula linear:
C5H6O5Na2
Número CAS:
103404-90-6
Peso molecular:
192.08
Beilstein:
5318041
Número MDL:
MFCD00069573
Código UNSPSC:
12352106
ID de substância PubChem:
329751400
NACRES:
NA.25

Nível de qualidade

100

Ensaio

≥98.0% (GC)

forma

powder or crystals

atividade óptica

[α]/D 8.5±1.5°, c = 1 in NaOH

Impurezas

≤6.0% water

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

chave InChI

DZHFTEDSQFPDPP-HWYNEVGZSA-L

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Ações bioquímicas/fisiológicas

Biomarker for inborn errors of metabolism and cancer

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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α-Ketoglutaric acid disodium salt dihydrate ≥98.0% (dried material, NT)

Sigma-Aldrich

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α-Ketoglutaric acid disodium salt dihydrate

α-Ketoglutaric acid BioReagent, suitable for cell culture, suitable for insect cell culture

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Glyceryl tridodecanoate ≥99%

Sigma-Aldrich

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Stefan Nowicki et al.
The FEBS journal, 282(15), 2796-2805 (2015-04-14)
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis. Recently, metabolites that can
Seth J Parker et al.
Pharmacology & therapeutics, 152, 54-62 (2015-05-10)
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of cancers, including acute myeloid leukemia (AML), low-grade gliomas, and chondrosarcomas. These mutations inactivate wild-type enzymatic activity and convey neomorphic function to produce d-2-hydroxyglutarate
M S Rashed et al.
Biomedical chromatography : BMC, 14(5), 317-320 (2000-08-29)
D-2-Hydroxyglutaric aciduria and L-2-hydroxyglutaric aciduria are two distinct inherited metabolic diseases. The accurate diagnosis of the exact disorder relies on the determination of the configuration of the enantiomers, either D-2-hydroxyglutaric acid or L-2-hydroxyglutaric acid excreted in excess in urine of
Martijn Kranendijk et al.
Journal of inherited metabolic disease, 35(4), 571-587 (2012-03-07)
The organic acidurias D: -2-hydroxyglutaric aciduria (D-2-HGA), L-2-hydroxyglutaric aciduria (L-2-HGA), and combined D,L-2-hydroxyglutaric aciduria (D,L-2-HGA) cause neurological impairment at young age. Accumulation of D-2-hydroxyglutarate (D-2-HG) and/or L-2-hydroxyglutarate (L-2-HG) in body fluids are the biochemical hallmarks of these disorders. The current
Andrew J Worth et al.
Chemical research in toxicology, 28(5), 948-954 (2015-03-25)
The α-ketoglutarate metabolite, 2-hydroxyglutarate (2-HG), has emerged as an important mediator in a subset of cancers and rare inherited inborn errors of metabolism. Because of potential enantiospecific metabolism, chiral analysis is essential for determining the biochemical impacts of altered 2-HG
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