Y0000563

Amitriptyline hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Sinônimo(s): AMT
• Fórmula empírica (Notação de Hill): C₂₀H₂₃N · HCl
• Número CAS: 549-18-8
• Peso molecular: 313.86
• Número MDL: MFCD00012537
• Código UNSPSC: 41116107
• ID de substância PubChem: 329831024
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: amitriptyline
• fabricante/nome comercial: EDQM
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• chave InChI: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Informações sobre genes: human ... SLC6A2(6530) , SLC6A4(6532)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Amitriptyline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301,H319,H361d,H410
• Declarações de precaução: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable