PHR1424

Ampicilina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): D-(−)-α-Aminobenzilpenicilina
• Fórmula empírica (Notação de Hill): C₁₆H₁₈N₃NaO₄S
• Número CAS: 69-52-3
• Peso molecular: 371.39
• Beilstein: 4119211
• Número CE: 200-708-1
• Número MDL: MFCD00064313
• Código UNSPSC: 41116107
• ID de substância PubChem: 329822591
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to BP 785; traceable to Ph. Eur. A1000000; traceable to USP 1033203
• família API: ampicillin
• Certificado de análise (CofA): current certificate can be downloaded
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• pf: 215 °C (dec.) (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: [Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
• chave InChI: KLOHDWPABZXLGI-YWUHCJSESA-M

Descrição

Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Ampicillin Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography with ultra violet detection and second-derivative spectrophotometry, respectively.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Modo de ação: Esse é um antibiótico ß-lactâmico que inibe a síntese da parede celular bacteriana por meio da inativação das transpeptidases na superfície interna da membrana celular bacteriana.

Modo de resistência: A administração com ß-lactamase cliva o anel ß-lactâmico da ampicilina, inativando-a.

Espectro da ação antimicrobiana: Inclui bactérias gram positivas (como a benzilpenicilina) e gram negativas (como as tetraciclinas e o cloranfenicol).

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA2732 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H317,H334
• Declarações de precaução: P261 - P280 - P342 + P311
• Classificações de perigo: Resp. Sens. 1 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable