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P7045

Supelco

Phenformin hydrochloride

analytical standard

Sinônimo(s):

N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride, Phenethylbiguanide

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About This Item

Fórmula empírica (Notação de Hill):
C10H15N5 · HCl
Número CAS:
834-28-6
Peso molecular:
241.72
Número CE:
212-637-3
Número MDL:
MFCD00035039
Código UNSPSC:
41116107
ID de substância PubChem:
329820259
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

Cl.NC(=N)NC(=N)NCCc1ccccc1

InChI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

chave InChI

YSUCWSWKRIOILX-UHFFFAOYSA-N

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Descrição geral

Phenformin hydrochloride is a biguanide derivative that shows anti-diabetic activity.

Aplicação

Phenformin hydrochloride has been used as a test compound to study the antineoplastic activity it can exhibit in suppressing the growth of ovarian cancer cells and also human hepatocellular carcinoma cells.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
MKCQ6399
MKCM5853
MKCJ5461
MKCF2089
MKCD3844

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Sigma-Aldrich

SAB4502329

Anti-AMPK α antibody produced in rabbit

Metformin hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

M-072

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Dorsomorphin ≥98% (HPLC)

Sigma-Aldrich

P5499

Dorsomorphin

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Sigma-Aldrich

T5580

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Metformin hydrochloride British Pharmacopoeia (BP) Reference Standard

BP227

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Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs
Hsu C-C, et al.
Oncology Reports, 34(3), 1620-1628 (2015)
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Segal D E, et al.
Biochemical and Biophysical Research Communications, 414(4), 694-699 (2011)
Ashley J Ovens et al.
The Biochemical journal, 479(11), 1181-1204 (2022-05-14)
The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new strategies to treat type
Arindam Mondal et al.
Scientific reports, 12(1), 13135-13135 (2022-07-31)
The imidazolium compound Ym155 was first reported to be a survivin inhibitor. Ym155 potently induces cell death of many types of cancer cells in preclinical studies. However, in phase II clinical trials Ym155 failed to demonstrate a significant benefit. Studies
Mozhgan Sedigh-Ardekani et al.
Regulatory toxicology and pharmacology : RTP, 70(2), 514-518 (2014-09-10)
Lactic acidosis occurs in a number of clinical conditions, e.g. in surgeries, orthotopic liver transplant, and anesthetic agent administration, which has deleterious effects on the patient's survival. The most rational therapy for these patients, the sodium bicarbonate administration, cannot prevent
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