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I7905

Sigma-Aldrich

Ibuprofen

meets USP testing specifications

Sinônimo(s):

α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

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About This Item

Fórmula empírica (Notação de Hill):
C13H18O2
Número CAS:
15687-27-1
Peso molecular:
206.28
Número CE:
239-784-6
Número MDL:
MFCD00010393
Código UNSPSC:
12352106
ID de substância PubChem:
24896130
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

Nível de qualidade

200

forma

solid

aplicação(ões)

pharmaceutical (small molecule)

cadeia de caracteres SMILES

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

chave InChI

HEFNNWSXXWATRW-UHFFFAOYSA-N

Informações sobre genes

human ... ALB(213) , ALOX5(240) , CYP1A2(1544) , CYP2C9(1559) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)
mouse ... Alox5(11689)
rat ... Alox5(25290) , Ptgs1(24693)

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Aplicação


  • A Case of Erythema Nodosum in a 20-Year-Old Female During the Postpartum Period.: Details a clinical case where ibuprofen was implicated in the treatment of erythema nodosum, offering insights into its therapeutic applications and associated risks (Nguyen M et al., 2024).

  • Coracoclavicular Joint Arthrosis - An Uncommon Cause of Shoulder Pain.: Investigates the use of ibuprofen in managing pain associated with rare joint disorders, contributing to broader understanding of pain management in orthopedic conditions (Graça NNJ et al., 2024).

Ações bioquímicas/fisiológicas

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H319,H335

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCG6368
SLCF0665
SLBZ4845
SLBW8573
SLBV1538

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Sigma-Aldrich

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Sigma-Aldrich

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Morshed A Chowdhury et al.
Journal of medicinal chemistry, 52(6), 1525-1529 (2009-03-20)
A novel class of 1-(4-methanesulfonylphenyl and 4-aminosulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole hybrid cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LOX) inhibitory anti-inflammatory agents was designed. Replacement of the tolyl ring present in celecoxib by the N-difluoromethyl-1,2-dihydropyrid-2-one moiety provided compounds showing dual selective COX-2/5-LOX inhibitory activities. 1-(4-Aminosulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole exhibited good anti-inflammatory
R O Day et al.
Clinical pharmacology and therapeutics, 43(5), 480-487 (1988-05-01)
The simultaneous disposition of the enantiomers of ibuprofen in synovial fluid and plasma was studied in eight patients with arthritis. Concentrations of the active S-enantiomer in synovial fluid exceeded those of the R-enantiomer at all times in all patients with
Bart Van Overmeire et al.
Lancet (London, England), 364(9449), 1945-1949 (2004-11-30)
Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed
J B Whitlam et al.
Clinical pharmacology and therapeutics, 29(4), 487-492 (1981-04-01)
Free and total ibuprofen levels in serum and synovial fluid (SF) were determined in one male and 14 female arthritic patients (mean age 56 yr, range 19 to 77) after 400 mg three times daily for 2 days. Free drug
Zhangjian Huang et al.
Journal of medicinal chemistry, 54(5), 1356-1364 (2011-02-02)
The carboxylic acid group of the anti-inflammatory (AI) drugs indo-methacin, (S)-naproxen and ibuprofen was covalently linked via a two-carbon ethyl spacer to a sulfohydroxamic acid moiety (CH(2)CH(2)SO(2)NHOH) to furnish a group of hybrid ester prodrugs that release nitric oxide (NO)
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