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Documentos Principais

F0060000

Fenticonazole nitrate

European Pharmacopoeia (EP) Reference Standard

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About This Item

Fórmula empírica (Notação de Hill):
C24H21Cl2N3O4S
Número CAS:
73151-29-8
Peso molecular:
518.41
Número MDL:
MFCD00941391
Código UNSPSC:
41116107
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

fenticonazole

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

S(c2ccc(cc2)COC(C[n]4cncc4)c3c(cc(cc3)Cl)Cl)c1ccccc1.[N+](=O)([O-])O

InChI

1S/C24H20Cl2N2OS.HNO3/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20;2-1(3)4/h1-14,17,24H,15-16H2;(H,2,3,4)

chave InChI

FJNRUWDGCVDXLU-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Fenticonazole nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

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W Speed et al.
Rapid communications in mass spectrometry : RCM, 9(14), 1452-1456 (1995-01-01)
A method is described for the determination of fenticonazole in human female plasma. The method utilizes high performance liquid chromatography coupled to atmospheric pressure positive-ion chemical ionization triple quadrupole mass spectrometry. Multiple reaction monitoring is employed for selectivity and sensitivity
A Novelli et al.
Journal of chemotherapy (Florence, Italy), 3(1), 23-27 (1991-02-01)
Fourteen women, five with normal cervicovaginal mucosa (Group 1), five with cervical carcinoma (Group 2) and four with relapsing vulvovaginal candidiasis (Group 3) were enrolled and completed this open clinical trial. Each subject received a single dose of 1.82 +/-
José Rodolfo Muñoz Reyes et al.
Ginecologia y obstetricia de Mexico, 70, 59-65 (2002-05-23)
Fenticonazole is an imidazole derivative with a broad-spectrum antifungal activity mainly against Candida albicans. Fenticonazole nitrate was compared to myconazole vs. test efficacy, tolerance and treatment compliance in-patients with mycotic vulvovaginitis. Eighty outpatients with mycotic vulvovaginitis were included and randomly
P Pigatto et al.
Arzneimittel-Forschung, 40(3), 329-331 (1990-03-01)
A double blind, randomized clinical trial was performed on twelve healthy volunteers to evaluate the irritation potential of fenticonazole 2% cream (Lomexin) and spray versus micomazole 2% cream and econazole 1% spray. The contact-sensitizing potential of the two fenticonazole preparations
A Di Silverio et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 124(9), XLVII-XLVIL (1989-09-01)
Thirty patients suffering from Pityriasis versicolor were treated with fenticonazole in cream or lotion form with two applications a day. At microscopy, Malassezia furfur was encountered in 25 cases and Pityrosporum orbiculare in 5. Disappearance of the yeast was obtained
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