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F0041000

Fenbufen

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

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About This Item

Fórmula linear:
C6H5C6H4CO(CH2)2CO2H
Número CAS:
36330-85-5
Peso molecular:
254.28
Número MDL:
MFCD00056701
Código UNSPSC:
41116107
ID de substância PubChem:
329799623
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

fenbufen

fabricante/nome comercial

EDQM

pf

184-187 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

chave InChI

ZPAKPRAICRBAOD-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Fenbufen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310 + P330

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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S S Kerwar
The American journal of medicine, 75(4B), 62-69 (1983-10-31)
Fenbufen (Cinopal) is an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity. Like clinically used nonsteroidal anti-inflammatory drugs, it shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs, and dogs. Fenbufen has a
R Andrew Moore et al.
The Cochrane database of systematic reviews, (4)(4), CD007547-CD007547 (2009-10-13)
Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. There is no known systematic review of its use in acute postoperative pain. To assess efficacy, duration of action, and associated adverse events of
C Kohler et al.
Arzneimittel-Forschung, 30(4A), 702-707 (1980-01-01)
gamma-Oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) and biphenylacetic acid have effects on platelets similar to other non-steroidal antiinflammatory agents. In vitro biphenylacetic acid (BPAA), a metabolite of fenbufen, is more potent than fenbufen and in vivo metabolism of fenbufen to BPAA is probably
A E Sloboda et al.
Arzneimittel-Forschung, 30(4A), 716-721 (1980-01-01)
gamma-Oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) was shown to be an orally and parenterally effective nonsteroidal antiinflammatory, analgesic and antipyretic agent in a variety of animal species. Like other clinically active antiinflammatory drugs such as acetylsalicylic acid (ASA), indometacin and phenylbutazone, fenbufen has
R N Brogden et al.
Drugs, 21(1), 1-22 (1981-01-01)
Fenbufen is a phenylalkanoic acid derivative with analgesic and anti-inflammatory activity. The anti-inflammatory activity appears to reside in the metabolites. Published data indicate that fenbufen 600 to 1000mg daily is comparable in effectiveness to therapeutic doses (3 to 4g) of

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