Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

BP368

Gliclazide

British Pharmacopoeia (BP) Reference Standard

Sinônimo(s):

1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea

Faça loginpara ver os preços organizacionais e de contrato


About This Item

Fórmula empírica (Notação de Hill):
C15H21N3O3S
Número CAS:
Peso molecular:
323.41
Número CE:
Número MDL:
Código UNSPSC:
12352125
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

gliclazide

forma

crystalline powder

prazo de validade

limited shelf life, expiry date on the label

fabricante/nome comercial

BP

pf

163-169 °C (lit.)

aplicação(ões)

pharmaceutical
pharmaceutical small molecule

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2

InChI

1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)

chave InChI

BOVGTQGAOIONJV-UHFFFAOYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Gliclazide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Gliclazide Tablets
  • Used in the treatment of non-insulin dependent diabetes mellitus (NIDDM).

    Ações bioquímicas/fisiológicas

    Oxidative modification of low-density lipoprotein (LDL) plays an important role in vascular dysfunction associated with diabetes mellitus. Gliclazide is a second-generation sulfonylurea with free-radical-scavenging activity. Incubation of human aortic smooth muscle cell (HASMC) with native human LDL (100 μg/mL) in the presence of increasing concentrations of gliclazide (1 to 10 μg/mL) resulted in a dose-dependent decrease in HASMC-mediated LDL oxidation. Exposure of HASMCs to gliclazide (1 to 10 μg/mL) and native LDL (100 μg/mL) also led to a dose-dependent decrease in oxidized LDL-induced human monocyte adhesion to HASMCs. In addition, incubation of HASMCs with gliclazide dramatically reduced the ability of oxidized LDL to stimulate the proliferation of these cells. Finally, treatment of HASMCs with gliclazide resulted in a marked decrease in oxidatively modified LDL-induced monocyte chemoattractant protein (MCP)-1 and human heat shock protein 70 (HSP 70) expression, both at the gene and protein levels. These results show that gliclazide, at concentrations in the therapeutic range (5 to 10 μg/mL), is effective in vitro in reducing vascular smooth muscle cell (VSMC) dysfunction induced by oxidatively modified LDL. Administration of gliclazide to type 2 diabetic patients could form part of the strategy for the prevention and management of diabetic cardiovascular diseases

    Embalagem

    Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Outras notas

    Sales restrictions may apply.

    Pictogramas

    Exclamation mark

    Palavra indicadora

    Warning

    Frases de perigo

    Declarações de precaução

    Classificações de perigo

    Acute Tox. 4 Oral

    Código de classe de armazenamento

    11 - Combustible Solids

    Classe de risco de água (WGK)

    WGK 2

    Ponto de fulgor (°F)

    Not applicable

    Ponto de fulgor (°C)

    Not applicable


    Escolha uma das versões mais recentes:

    Certificados de análise (COA)

    Lot/Batch Number

    Lamentamos, não temos COA para este produto disponíveis online no momento.

    Se precisar de ajuda, entre em contato Atendimento ao cliente

    Já possui este produto?

    Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

    Visite a Biblioteca de Documentos

    Os clientes também visualizaram

    Slide 1 of 2

    1 of 2

    Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

    Entre em contato com a assistência técnica