SCT247

BioTracker MultiTASQ G-Quadruplex (G4) Cell Probe

• Sinônimo(s): G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe, click chemistry probe
• Código UNSPSC: 41106514
• NACRES: NA.52

Propriedades

• embalagem: vial of 1 mg
• Nível de qualidade: 100
• fabricante/nome comercial: Millipore
• modo de crescimento: N/A
• técnica(s): DNA sequencing: suitable; RNA extraction: suitable; nucleic acid detection: suitable
• método de detecção: fluorometric
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C

Descrição

Aplicação

DNA/RNA G-quadruplexes (G4s) are four-stranded nucleic acid structures that fold from numerous guanine (G)-rich sequences found in the genome and transcriptome. Their abundance and localization in critical regulatory regions make them key players in genetic diseases (cancer, neuropathology), but not only (e.g., viral infection). For this reason G4s have garnered intense interest as potential targets in different therapeutic areas
The BioTracker^™ MultiTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). MultiTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914

Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.

Características e benefícios

MultiTASQ detects ribosomal RNA-G4 associated with perinuclear rough ER regions to a greater degree compared to BG4 antibody. MultiTASQ is an alkynylated probe that allows for background-free detection via click chemistry and is suitable for G4 capture chemi-precipitation and click imaging applications. MultiTASQ is compatible with live-cell incubation. The BioTracker MultiTASQ G4 cell probe is a uniquely designed, versatile tool for G4 detection and analysis.

forma física

Lyophilized. White solid.

Armazenamento e estabilidade

Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light

Outras notas

Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues using click chemistry

Informações legais

BioTracker is a trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable