SCC131
A2EN Human Endocervical Epithelial Cell Line
Human
Sinônimo(s):
A2EN Cell Line
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About This Item
Código UNSPSC:
41106514
eCl@ss:
32011203
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Nome do produto
A2EN Human Endocervical Epithelial Cell Line, A2EN endocervical epithelial cell line can be used to study sexually transmitted pathogen infections, pathogenesis and the innate immune response.
fonte biológica
human
Nível de qualidade
técnica(s)
cell culture | mammalian: suitable
Descrição geral
A2EN is an immortalized human epithelial cell line derived from human primary epithelial cells expanded from an explant of human endocervical tissue. The primary endocervical epithelial cells were immortalized with lentiviral vectors carrying the HPV E6/E7 genes. A2EN cells can generate a transepithelial electrical resistance (TEER) when grown on cell culture inserts and generate differential apical and basolateral cytokine profiles upon stimulation with various toll-like receptor (TLR) agonists.
The endocervical epithelium is a single cell layer lining the endocervical canal that separates the lower female reproductive tract from the uterus and Fallopian tubes. Endocervical epithelial cells secrete mucus and innate immune mediators that facilitate reproduction as well as protect from pathogen invasion. The endocervix is a major site of transmission for multiple sexually transmitted organisms, such as Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and human immunodeficiency virus (HIV).
Descrição de linhagem celular
Epithelial Cells
Aplicação
A2EN endocervical epithelial cell line can be used to study sexually transmitted pathogen infections, pathogenesis and the innate immune response.
Research Category
Infectious Diseases
Immune Response
Infectious Diseases
Immune Response
This product is intended for sale and sold solely for internal non-commercial research use per the terms of the “Restricted Use Agreement” as detailed in the product documentation. For information regarding any other uses, please contact licensing@emdmillipore.com.
Qualidade
• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for Epstein-Barr virus, HPV-16, HPV-18, Hepatitis A, C, Herpesvirus type 6, 7, 8 and HIV-1 & 2 viruses by PCR
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
• Cells are tested negative for Epstein-Barr virus, HPV-16, HPV-18, Hepatitis A, C, Herpesvirus type 6, 7, 8 and HIV-1 & 2 viruses by PCR
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Armazenamento e estabilidade
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Exoneração de responsabilidade
This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges {HCompany} to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
does not flash
Ponto de fulgor (°C)
does not flash
Certificados de análise (COA)
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Lyndsey R Buckner et al.
Journal of reproductive immunology, 92(1-2), 8-20 (2011-09-29)
The endocervix in the female reproductive tract (FRT) is susceptible to sexually transmitted pathogens such as Chlamydia trachomatis and Neisseria gonorrhoeae. Endocervical epithelial cells in vivo make innate immune mediators that likely aid in the protection from these pathogens. In
Mohammad Iqbal Rather et al.
The Journal of biological chemistry, 289(2), 968-976 (2013-11-22)
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IUBMB life, 71(10), 1595-1610 (2019-06-30)
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