SCC071
UM-SCC-47 HPV-16 Positive Squamous Carcinoma Cell Line
Human
Sinônimo(s):
University Michigan Squamous Cell Carcinoma, UMSCC47, H&N squamous cell carcinoma cell line, Head and neck squamous cell carcinoma cell line, HNSCC
About This Item
Produtos recomendados
Nome do produto
UM-SCC-47 HPV-16 Positive Squamous Carcinoma Cell Line, suitable in vitro model of H&N carcinoma studies
fonte biológica
human
Nível de qualidade
técnica(s)
cell culture | mammalian: suitable
Condições de expedição
liquid nitrogen
Descrição geral
THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com
Head and neck squamous-cell carcinoma (HNSCC) is the 6th most common type of cancer world-wide. The cancer may occur in the lip, oral cavity, nasal cavity, paranasal sinuses, salivary glands, pharynx and larynx. Risk factors include smoking, alcohol consumption, betel nut chewing, wood dust exposures and human papilloma virus (HPV) infections. Approximately 15% of HNSCC contain genomic DNA from HPV. In particular, HPV-16 occurs in 90-95% of all HPV-positive HNSCC cases. In oral and pharynx cancer, HPV DNA is found in the tonsils in 45-67% of the cases. HPV DNA is found in 13-25% of the cases in the hypopharynx, 12-18% in the oral cavity and 3-7% in the larynx.
UM-SCC-47 is a unique head and neck squamous carcinoma cell line isolated from the primary tumor of the lateral tongue of a male patient. The cell line contains 18 copies of integrated HPV-16.
UM-SCC-47 was established at the University of Michigan with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.
Reference:
1) Carey, T., et al. (2012) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 April; 32(4): 417–426.
Descrição de linhagem celular
Aplicação
Infectious Diseases
Inflammation & Immunology
Apoptosis & Cancer
Componentes
Qualidade
• Cells are tested by PCR and are positive for HPV-16 and negative for Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
Armazenamento e estabilidade
Exoneração de responsabilidade
Código de classe de armazenamento
6.2 - Infectious substances
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Artigos
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