RLI1MAG-92K
MILLIPLEX® Rat Liver Injury Panel - Toxicity Multiplex Assay
Sinônimo(s):
Luminex® Rat Liver Toxicity Assay, Millipore Rat Liver Toxicity Assay, Rat Liver Injury Multiplex Panel
About This Item
Produtos recomendados
descrição
The analytes available for this multiplex kit are: Liver-type arginase 1 (ARG1), aspartate transaminase 1 (GOT1), α-glutathianone S-transferase (GSTα), sorbitol dehydrogenase (SDH), and 5′-Nucleotidase (5′-NT/CD73).
Nível de qualidade
reatividade de espécies
rat
fabricante/nome comercial
Milliplex®
assay range
accuracy: 77-92%
sensitivity: 0.021-4.038 ng/mL
(MinDC+2SD)
standard curve range: 0.02-15.0 ng/mL
(GSTα)
standard curve range: 0.04-30.0 ng/mL
(5′-NT/CD73)
standard curve range: 0.08-60.0 ng/mL
(GOT1)
standard curve range: 0.10-75.0 ng/mL
(ARG1)
standard curve range: 0.62-450.0 ng/mL
(SDH)
técnica(s)
multiplexing: suitable
método de detecção
fluorometric (Luminex xMAP)
Condições de expedição
wet ice
Categorias relacionadas
Descrição geral
*ARG1, GSTα, and SDH are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing.
The MILLIPLEX® portfolio provides a valuable research assay to investigate multiple biomarkers of liver injury in rat serum and plasma samples using the Luminex® xMAP® instrument platform. This kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.
Drug toxicity is the leading cause of acute liver failure in the United States. Patients with liver damage generally display elevated amounts of specific liver proteins in serum; these proteins can serve as biomarkers of drug-related liver toxicity. Monitoring these biomarkers can greatly help clinicians avoid drug-induced liver failure. Performing laboratory tests to characterize the side effects of potential therapeutics is an essential part of drug development. The rat is a leading animal model for these pre-clinical toxicity studies. The search for sensitive, organ-specific toxicity biomarkers is complemented by the development of novel assays to measure these critical analytes. Liver-Type Arginase 1 (ARG1), α-glutathione S-transferase (GSTα), and Sorbitol Dehydrogenase (SDH) are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. Aspartate transaminase 1 (GOT1) and 5′-Nucleotidase / CD73 (5′-NT) are traditional biomarkers recognized by both the Food and Drug Administration (FDA) and its European counterpart, the European Medicines Agency (EMA).
Panel Type: Toxicity
Aplicação
- Analytes: 5′-Nucleotidase (5′-NT/CD73), Liver-Type Arginase 1 (ARG1), Aspartate transaminase 1 (GOT1), α-Glutathione S-Transferase (GSTα), Sorbitol Dehydrogenase (SDH)
- Recommended Sample Type: Rat serum and plasma
- Recommended Sample Dilution: 25 μL per well of 1:25 diluted serum or plasma
- Assay Run Time: 2 hours at room temperature (20-25°C)
- Research Category: Toxicity
Características e benefícios
Componentes
Rat Liver Injury Quality Control 1, 1 vial, lyophilized
Rat Liver Injury Quality Control 2, 1 vial, lyophilized
Assay Buffer, 1 bottle, 30 mL
Wash Buffer, 10X (0.05% Proclin), 2 bottles, 30 mL ea
Rat Liver Injury Detection Antibodies, 1 bottle, 3.2 mL
Streptavidin-Phycoerythrin, 1 bottle, 3.2 mL
Mixing Bottle, 1 bottle
Sample Plate, 96 well format, 1 plate
2 Foil Plate Sealers
Outras notas
Informações legais
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Certificados de análise (COA)
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Conteúdo relacionado
See how multiplex assays, such as the Luminex® bead-based multiplex immunoassay MILLIPLEX® Rat Liver Injury Panel, enable researchers to simultaneously measure multiple hepatotoxic biomarkers and cytokines to expand knowledge on drug-induced liver injury processes.
Learn the benefits of using biomarker detection multiplex immunoassays for laboratory, companion, and agricultural animal research and explore MILLIPLEX® multiplex assays for veterinary medicine and animal health research.
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