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MADCYMAG-72K

Millipore

MILLIPLEX® Mouse Adipocyte Magnetic Panel - Endocrine Multiplex Assay

The analytes available for this multiplex kit are: Adiponectin, IL-6, Leptin, MCP-1, PAI-1 (Total), Resistin, TNF-α.

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About This Item

Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Nível de qualidade

200

reatividade de espécies

mouse

fabricante/nome comercial

Milliplex®

assay range

accuracy: 85-98%
standard curve range: 12.2-50,000 pg/mL

técnica(s)

multiplexing: suitable

método de detecção

fluorometric (Luminex xMAP)

Condições de expedição

wet ice

Categorias relacionadas

Descrição geral

The role of white adipose tissue was thought to be limited to energy storage and internal organ protection. The discovery of leptin secretion from adipocytes in 1994 led to the recognition that white adipose tissue is involved in a variety of metabolic and physiological processes. Adipocytes secrete several hormones called adipokines with functions that include appetite and energy balance, insulin sensitivity and lipid metabolism. One of these adipokines, adiponectin, is involved in the regulation of lipid and glucose metabolism, influencing the body′s response to insulin. Its anti-inflammatory effects on the cellular lining of blood vessel walls may explain the association of high adiponectin levels with a reduced risk of heart attack.

MILLIPLEX® Mouse Adipocyte Panel is a 7-plex kits used for the simultaneous quantification of any or all of the following analytes in mouse tissue culture supernatant samples: Adiponectin, IL-6, Leptin, MCP-1, PAI-1 Total, Resistin and TNFα. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Metabolism

Aplicação

  • Analytes: Adiponectin, IL-6, Leptin, MCP-1, PAI-1 (Total), Resistin, TNFα
  • Recommended Sample Type: Mouse tissue culture supernatants
  • Recommended Sample Dilution: 10 μL per well of tissue culture supernatant; dilution with an appropriate control medium may be required.
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C or 2 hours at room temperature (20-25°C).
  • Research Category: Metabolism
  • Research Subcategory: Endocrine, Obesity, Metabolic Disorders

Características e benefícios

Design your multiplex kit by choosing available analytes within this panel.

Outras notas

Sensitivity: Please see kit protocol for sensitive’s of individual biomarkers.

Informações legais

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Código de classe de armazenamento

10 - Combustible liquids

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Gabriela Martínez-Chacón et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(5), e21536-e21536 (2021-04-30)
Obesity is a risk factor for postmenopausal breast cancer. Obesity-related inflammation upregulates aromatase expression, the rate-limiting enzyme for estrogen synthesis, in breast adipose tissue (BAT), increasing estrogen production and cancer risk. The regulation of aromatase gene (CYP19A1) in BAT is
Nasser M Rizk et al.
Journal of inflammation research, 14, 1743-1757 (2021-05-14)
Obesity is a chronic disorder characterized by a low-grade inflammatory state and immune cell irregularities. The study aimed to follow up on the changes in the peripheral CD4+ T lymphocytes and the pro-inflammatory cytokines; IL-6, TNF-alpha, MCP-1, and IL-10 at

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Multiplex immunoassays, such as MILLIPLEX® multiplex metabolic assays, are critical in metabolic syndrome research because they provide a full picture of the different conditions related to it, like diabetes and obesity, as well as save time and sample volume.

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