MABS279

Anti-GPR30, clone 2F2 Antibody

clone 2F2, from mouse

• Sinônimo(s): G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 2F2, monoclonal
• reatividade de espécies: human
• técnica(s): immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_001035055
• nº de adesão UniProt: Q99527
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... GPER1(2852)

Descrição

Descrição geral

GPR30, also known as G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1 (FEG-1), G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor (LYGPR), or Membrane estrogen receptor (mER), and encoded by the gene GPER/CEPR/CMKRL2/DRY12/GPR30,is the common receptor for estrogen. GPR30 binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus, and therefore GPR30 is part of the rapid non-genomic signaling events widely observed when cells interact with estrogen. GPR30 is a cell membrane bound protein found in the Golgi apparatus, endoplasmic reticulum and plasma membrane. GPR30 is ubiquitously expressed, but is most abundant in placenta. In brain regions, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.

Imunogênio

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human GPR30.

Aplicação

Detect GPR30 using this Anti-GPR30 antibody, clone 2F2 validated for use in IHC & IP.

Immunoprecipitation Analysis: A representative lot from an independent laboratory detected GPR30 in HEK293 cell lysate (Filardo, E., et al. (2007). Endocrinology. 148(7):3236-3245.).

Research Category
Signaling

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Qualidade

Evaluated by Immunohistochemistry in human placenta tissues.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected GPR30 in human placenta tissues.

Descrição-alvo

42 kDa calculated

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable