MABN851

Anti-CRALBP Antibody, clone 3H9.1

clone 3H9.1, from mouse

• Sinônimo(s): Retinaldehyde-binding protein 1, Cellular retinaldehyde-binding protein, CRALBP
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified antibody
• tipo de produto de anticorpo: primary antibodies
• clone: 3H9.1, monoclonal
• reatividade de espécies: mouse
• reatividade da espécie (prevista por homologia): human (based on 100% sequence homology)
• técnica(s): western blot: suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_000317
• nº de adesão UniProt: P12271
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... RLBP1(6017)

Descrição

Descrição geral

Retinaldehyde-binding protein 1 (UniProt P12271; also known as Cellular retinaldehyde-binding protein) is encoded by the RLBP1 (also known as CRALBP) gene (Gene ID 6017) in human. CRALBP is a retinoid-binding protein expressed in retinal pigment epithelial (RPE) cells and Müller glia involved in the retinal visual cycle. Photoactivation of a visual pigment molecule in vertebrate rod and cone photoreceptors renders the pigment molecule into a bleached all-trans retinal form, which must be exported out of the photoreceptors to be converted back to the light-sensitive 11-cis retinal form in RPE cells (for both rods and cones) or in retinal Müller glia (for cones only). The 11-cis chromophore is then imported back into photoreceptors, where it combines with a free opsin to regenerate the visual pigment. CRALBP is a 36 kDa water-soluble protein that facilitates the intracellular transport of hydrophobic 11-cis retinoids. Mutations in human RLBP1 cause several autosomal recessive retinal diseases, such as retinitis pigmentosa, Bothnia dystrophy, retinitis punctata albescens, fundus albipunctatus, and Newfoundland rod-cone dystrophy. Likewise, Rlbp1-knockout mice exhibit M-opsin mislocalization, M-cone loss, and impaired cone-driven visual behavior and light responses. Viral expression of CRALBP in Müller cells, but not RPE cells, is reported to rescue the retinal visual cycle and M-cone sensitivity in Rlbp1-knockout mice.

Imunogênio

Epitope: N-terminal half.

GST-tagged recombinant protein corresponding to the N-terminal half of human CRALBP.

Aplicação

Research Category
Neuroscience

Research Sub Category
Sensory & PNS

Qualidade

Evaluated by Western Blotting in mouse retina tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CRALBP in 10 µg of mouse retina tissue lysate.

Descrição-alvo

~36 kDa observed.

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable