MABN748

Anti-TrpC3, clone 10H6 Antibody

clone 10H6, from mouse

• Sinônimo(s): Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 10H6, monoclonal
• reatividade de espécies: mouse
• reatividade da espécie (prevista por homologia): human (based on 100% sequence homology)
• técnica(s): western blot: suitable
• Isotipo: IgG1
• nº de adesão NCBI: NP_001124170
• nº de adesão UniProt: Q13507
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TRPC3(7222)

Descrição

Descrição geral

TrpC3, also known as Short transient receptor potential channel 3, transient receptor protein 3 or TRP-3, and encoded by the gene TRPC3/TRP3, forms a receptor activated calcium channel that is activated via ligand binding and transduces signals via the G-protein coupled tyrosine receptor kinases pathways.TrpC3 can also be activated by the release of internal calcium and is one of the principal receptors involved in maintaining Ca++ ion homeostasis in skeletal muscles and nervous tissue. TrpC3 is also a principal receptor involved in the Capacitative calcium entry (CCE) which is the mechanism behind Ca++ influx into cells that replenishes internal calcium stores. Additionally, TrpC3 receptor is important in axon guidance, phototransduction, and platelet activation. TrpC3 is localized to the cell membrane and consists of a multipass-though transport protein. TrpC3 is expressed principally in the brain but is also found in most other tissues and organs at lowered levels.

Imunogênio

Recombinant protein corresponding to mouse TrpC3.

Aplicação

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-TrpC3, clone 10H6 Antibody is validated for use in Western Blotting for the detection of TrpC3.

Western Blotting Analysis: A representative lot detected TrpC3 in cerebellar tissues of TRPC3 wild type mice and not TRPC3 knock out mice (Prof. Yizheng Wang, Shanghai Institutes for Biological Sciences (SIBS).
Western Blotting Analysis: A representative lot detected TrpC3 in rat liver and brain tissue lysates (Feng. S., et al. (2013). PNAS. 1-6).

Qualidade

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TrpC3 in 10 µg of mouse brain tissue lysate.

Descrição-alvo

~110 kDa observed.

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable