MABF2042

Anti-TSLP Receptor Antibody, clone 1A6

clone 1A6, from mouse

• Sinônimo(s): Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLPR
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• clone: 1A6, monoclonal
• application: FACS
• reatividade de espécies: human
• técnica(s): flow cytometry: suitable

Propriedades

• fonte biológica: mouse
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 1A6, monoclonal
• reatividade de espécies: human
• embalagem: antibody small pack of 25 μg
• técnica(s): flow cytometry: suitable
• Isotipo: IgG2aλ
• nº de adesão NCBI: NP_071431.2
• nº de adesão UniProt: Q9HC73
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CRLF2(64109)

Descrição

Descrição geral

Cytokine receptor-like factor 2 (UniProt: Q9HC73; also known as Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor) is encoded by the CRLF2 (also known as CRL2, ILXR, TSLPR) gene (Gene ID: 64109) in human. TSLP receptor is a single-pass type I membrane protein that serves as a receptor for thymic stromal lymphopoietin. It forms a functional complex with TSLP and IL7R to stimulate cell proliferation via activation of STAT3 and STAT5. It is primarily expressed in dendrites and monocytes and its expression has also been reported in heart, skeletal muscle, kidney and liver. Its levels are up-regulated in activated peripheral monocytes and THP-1 cells. TSLP receptor is synthesized with a signal peptide (aa 1-21), which is subsequently cleaved off in the mature form. It contains an extracellular domain (aa 23-231), a transmembrane domain (aa 232-252), and a cytoplasmic domain (aa 253-371). It also has a WSXWS motif (aa 200-204) that is essential for proper protein folding and efficient intracellular transport and cell-surface binding. In addition, its Box 1 motif (aa 261-269) is reported to be important for its association with JAKs. Three isoforms of TSLP receptors have been described that are produced by alternative splicing.

Especificidade

Clone 1A6 specifically detects human TSLP receptor protein. It targets an epitope with in the extracellular domain.

Imunogênio

Epitope: extracellular domain

Fc-fusion protein of ectodomain region of human TSLP receptor protein.

Aplicação

Anti-TSLP Receptor, clone 1A6, Cat. No. MABF2042, is a mouse monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.

Research Category
Inflammation & Immunology

Qualidade

Evaluated by Flow Cytometry in one million THP-1 monocytic peripheral blood cells.

Flow Cytometry Analysis: 1 µg of this antibody detected TSLP Receptor in one million THP-1 monocytic peripheral blood cells.

Descrição-alvo

42.01 kDa calculated.

forma física

Format: Purified

Protein G purified

Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable