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Documentos Principais

MAB5276

Sigma-Aldrich

Anti-Endorphin β Antibody, clone 3-E7

clone 3-E7, Chemicon®, from mouse

Sinônimo(s):

Anti-ACTH

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

3-E7, monoclonal

reatividade de espécies

pig, human

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunohistochemistry: suitable

Isotipo

IgG2a

nº de adesão NCBI

NM_000939.2
NM_001035256.1

nº de adesão UniProt

P01189

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... POMC(5443)

Especificidade

The antibody reacts with the amino terminal H-Tyr-Gly-Gly-Phe sequence of human O-endorphin. Therefore, a high cross-reactivity with homologues of identical sequence, such as [Met]-enkephalin and [Leu]-enkephalin and a number of opioid peptides, occurs; the antibody also reacts with swine and camel O-endorphin. However, the antibody does not recognize human beta-lipotropin and N-acetyl-beta-endorphin (Gramsch et al., 1983; Meo et al., 1983; Herz et al., 1982).

Imunogênio

Synthetic human beta-endorphin coupled with poly-lysine or thyroglobulin (Gramsch et al., 1983; Meo et al., 1983) (H-Tyr-Gly-Gly-Phe sequence).

Aplicação

ELISA Immunohistochemistry

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neuroinflammation & Pain

Hormones & Receptors
This Anti-Endorphin Antibody, β, clone 3-E7 is validated for use in ELISA, IH for the detection of Endorphin.

forma física

Format: Purified
Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25M NaCl and 0.1% sodium azide.

Armazenamento e estabilidade

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Binding characteristics of a monoclonal beta-endorphin antibody recognizing the N-terminus of opioid peptides.
Gramsch, C, et al.
Journal of Neurochemistry, 40, 1220-1226 (1983)
W H Oertel et al.
Life sciences, 33 Suppl 1, 73-76 (1983-01-01)
Opioid peptide-like (OPL)-immunoreactivity and (the GABA-biosynthetic enzyme) glutamic acid decarboxylase-like (GAD)-immunoreactivity were localized in rat neostriatum and central amygdaloid nucleus (ACE) using a polyclonal sheep antiserum to rat brain GAD and a monoclonal mouse antibody to the N-terminus of beta-endorphin
Fernanda B Lima et al.
Brain research, 1663, 1-8 (2017-03-13)
With the decline of ovarian steroids levels at menopause, many women experience an increase in anxiety and stress sensitivity. The locus coeruleus (LC), a central source of noradrenaline (NE), is activated by stress and is inhibited by β-endorphin. Moreover, increased
Characteristics of a monoclonal beta-endorphin antibody recognizing the N-terminus of opioid peptides.
Herz, A, et al.
Life Sciences, 31, 1721-1724 (1982)
Monoclonal antibody to the message sequence Tyr-Gly-Gly-Phe of opioid peptides exhibits the specificity requirements of mammalian opioid receptors.
Meo, T, et al.
Proceedings of the National Academy of Sciences of the USA, 80, 4084-4088 (1983)

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