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Key Documents

MAB5260

Sigma-Aldrich

Anti-Nerve Growth Factor Antibody, clone 27/21

clone 27/21, Chemicon®, from mouse

Sinônimo(s):

NGF

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

27/21, monoclonal

reatividade de espécies

human, rat, mouse, bovine

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable

Isotipo

IgG1

nº de adesão NCBI

NM_001102654.1
NM_002527.4

nº de adesão UniProt

P20783

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... NTF3(4908)

Especificidade

NGF is a neurotrophic protein which is synthesized by the target tissues of NGF-sensitive neurons. NGF acts on sympathetic and sensoric neurons as well as on cholinergic neurons of the basal forebrain. It has been suggested that NGF is involved in the neuropathology of Alzheimer′s Disease (Hefti & Weiner, 1986). In the peripheral nervous system, NGF plays a role in the development of autonomic and sensory neuropathies (Anand et al., 1991).

The antibody specifically reacts with the beta -subunit of NGF from mouse, in the 2.5S- as well as in the 7S-form.

The cross-reactivity with human NGF is 60-90 % of the reactivity with mouse NGF

Imunogênio

2.5 S form of mouse NGF.

Aplicação

ELISA

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins
This Anti-Nerve Growth Factor Antibody, clone 27/21 is validated for use in ELISA for the detection of Nerve Growth Factor.

forma física

Format: Purified
Purified immunoglobulin. Lyophilized from 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. Reconstitute with 1 mL of sterile distilled water.

Armazenamento e estabilidade

The lyophilized antibody is stable if stored dry at 2-8°C for up to 12 months. After reconstitution maintain at 4°C unaliquotted but sealed tightly for 6 months; do not freeze thaw.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H302 + H332,H311,H411

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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New autonomic and sensory neuropathy with loss of adrenergic sympathetic function and sensory neuropeptides.
Anand, P, et al.
Lancet, 337, 1253-1254 (1991)
Nerve growth factor: mechanism of action.
Vinores, S and Guroff, G
Annual Review of Biophysics and Bioengineering, 9, 223-257 (1980)
Deoxyribonucleic acids and related compounds. XXII. Synthesis of genes for human nerve growth factor and its fused protein.
Iwai, S, et al.
Chemical & Pharmaceutical Bulletin, 34, 4724-4730 (1986)
Nerve growth factor (NGF) is present in human placenta and semen, but undetectable in normal and Paget's disease blood: measurements with an anti-mouse-NGF enzyme immunoassay using a recombinant human NGF reference.
Heinrich, G and Meyer, T E
Biochemical and biophysical research communications, 155, 482-486 (1988)
L Velasco et al.
European journal of biochemistry, 268(3), 531-535 (2001-02-13)
Cannabinoids, the active components of marihuana, exert a variety of effects in humans. Many of these effects are mediated by binding to two types of cannabinoid receptor, CB1 and CB2. Although CB1 is located mainly in the central nervous system
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