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Key Documents

MAB371

Sigma-Aldrich

Anti-Cranin Antibody, aa572-604 of human sequence, clone 6C1

ascites fluid, clone 6C1, Chemicon®

Sinônimo(s):

alpha-dystroglycan

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

6C1, monoclonal

reatividade de espécies

mouse, sheep, rat, human, chicken, Xenopus

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable

Isotipo

IgM

nº de adesão UniProt

Q9TS66

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... DAG1(1605)

Especificidade

Cranin (dystroglycan), extracellular site, near the C-terminus of the alpha-subunit. The expression and localization of cranin varies considerably according to the cells physiologic state and differentiaion state. MAB371 recognizes the same peptide region as MAB373 but a different epitope.

Imunogênio

Epitope: aa572-604 of human sequence
Synthetic peptide corresponding to a.a. 572-604 of human cranin.

Aplicação

Immunohistochemistry on tissue fixed briefly with 0.5% glutaraldehyde, 2% PLP fixation, methanol or acetone. Prolonged fixation must be avoided. Traditional formalin is not recommended. Suggested working dilution 1:1-1:50.

Immunocytochemistry on neuron, astrocyte, smooth muscle, fibroblast and epithelial cell lines.

ELISA

Not suggested for use in Western blot.

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure

Cell Structure
Research Sub Category
Cytoskeleton

ECM Proteins
This Anti-Cranin Antibody, aa572-604 of human sequence, clone 6C1 is validated for use in ELISA, IC, IH for the detection of Cranin.

forma física

Ascites Liquid.

Armazenamento e estabilidade

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Purificaiton of Cranin, a laminin binding membrane protein
Smalheiser, NR and Kim, E.
The Journal of Biological Chemistry, 270, 15425-15433 (1995)
B J Collins et al.
Endocrinology, 142(7), 3152-3162 (2001-06-21)
Dystroglycan is a high affinity laminin-binding glycoprotein originally described as a member of the dystrophin-associated glycoprotein complex in muscle. We have demonstrated the presence of dystroglycan in the thyroid using immunocytochemistry, immunoblots, ligand binding assays, and relative quantitative RT-PCR. In
X Li et al.
The Journal of cell biology, 153(4), 811-822 (2001-05-16)
Fibroblast growth factors and receptors are intimately connected to the extracellular matrix by their affinity to heparan sulfate proteoglycans. They mediate multiple processes during embryonic development and adult life. In this study, embryonic stem cell-derived embryoid bodies were used to

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