MAB1961

Anti-Integrin αVβ5 Antibody, clone P1F6

clone P1F6, Chemicon^®, from mouse

• Sinônimo(s): Anti-CD51, Anti-MSK8, Anti-VNRA, Anti-VTNR
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: P1F6, monoclonal
• reatividade de espécies: human, chicken
• fabricante/nome comercial: Chemicon^®
• técnica(s): flow cytometry: suitable; immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• Isotipo: IgG1
• adequação: not suitable for immunohistochemistry (Paraffin)
• nº de adesão NCBI: NM_002210.2
• nº de adesão UniProt: P06756
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... ITGAV(3685)

Descrição

Descrição geral

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha V chain. Alpha chain V undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Especificidade

Reacts with the human integrin alphaVbeta5.

Imunogênio

Human UCLA P3 cells (lung carcinoma)

Aplicação

Inhibition of attachment of HT29 cells to vitronectin: >1:1,000

Inhibition of attachment of carcinoma and melanoma cells to vitronectin.

Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue. (Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 min.)

Immunocytochemistry: 1:1500. For use on human carcinomas, normal epithelium and keratinocytes (Acetone Fixed Only).

Immunoprecipitation

FACS

EIA

Optimal working dilutions must be determined by the end user.

Research Category
Cell Structure

Research Sub Category
Integrins

This Anti-Integrin αVβ5 Antibody, clone P1F6 is validated for use in FC, IC, IH, IP, FUNC for the detection of Integrin αVβ5.

forma física

Format: Purified

Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.

Protein A purified

Armazenamento e estabilidade

Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análise

Control
Epithelium, keratinocytes

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable