MAB1598
Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8
clone 7E3-1B8, Chemicon®, from mouse
Sinônimo(s):
PSD-95
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
7E3-1B8, monoclonal
reatividade de espécies
bovine, rat, mouse
reatividade da espécie (prevista por homologia)
human
fabricante/nome comercial
Chemicon®
técnica(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG1
nº de adesão UniProt
Condições de expedição
dry ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
bovine ... Dlg4(100137840)
human ... DLG4(1742)
mouse ... Dlg4(13385)
rat ... Dlg4(29495)
Descrição geral
The postsynaptic density (PSD) is an electron dense structure just beneath the postsynaptic membrane. Several functions have been proposed for the PSD including regulating receptor number and clustering, anchoring signal transduction molecules at the synapse and mediating adhesion between the presynaptic and postsynaptic membranes. The most abundant PSD protein is the [alpha] subunit of the type II calcium/calmodulin dependent protein kinase ([alpha]CaMKII). This protein is likely to play a role in the calcium-mediated signal transduction at the synapse that mediates certain forms of synaptic plasticity. Another major PSD protein is PSD-95, a member of the guanylate kinase family (GUK) of proteins.
Especificidade
Reacts with recombinant rat PSD-95 and identifies a band at approximately ~100 kDa, corresponding to PSD-95, on western blots of rat brain, mouse brain and bovine brain extracts. Also present in rat brain and mouse brain tissue extracts are bands of approximately 80 kDa and 50 kDa. PSD-95 is believed to initiate NMDA receptor clustering on the post synaptic membrane.
Imunogênio
Recombinant rat PSD-95
Aplicação
Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8 is an antibody against Post Synaptic Density Protein 95 for use in IC, IP & WB.
Immunocytochemistry:
A previous lot of this antibody was used in IC.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Optimal working dilutions must be determined by the end user.
A previous lot of this antibody was used in IC.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Optimal working dilutions must be determined by the end user.
Qualidade
Evaluated by Western Blot on Mouse brain lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected PSD-95 on 10 µg of Mouse brain lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected PSD-95 on 10 µg of Mouse brain lysates.
Descrição-alvo
~ 95 kDa
Ligação
Replaces: 04-1066
forma física
Format: Purified
Purified mouse monoclonal IgG1 liquid in buffer containing PBS, pH 7.2, with 0.09% sodium azide and 50% glycerol.
Nota de análise
Control
Mouse brain, rat brain tissue
Mouse brain, rat brain tissue
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Kerti, K; Lorincz, A; Nusser, Z
The European Journal of Neuroscience null
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
Zheng, S; Gray, EE; Chawla, G; Porse, BT; O'Dell, TJ; Black, DL
Nature Neuroscience null
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