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HNDG1MAG-36K

Millipore

MILLIPLEX® Human Neurodegenerative Disease Magnetic Bead Panel 1 - Neuroscience Multiplex Assay

The analytes available for this multiplex kit are: α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3 and Complement Factor H.

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About This Item

Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Nível de qualidade

200

reatividade de espécies

human

fabricante/nome comercial

Milliplex®

assay range

accuracy: 105%
(Complement Factor H)
accuracy: 110%
(Apo E)
accuracy: 75%
(Complement C3)
intra-assay cv: <10
standard curve range: 0.01-40 ng/mL
(Apo CIII)
standard curve range: 0.05-200 ng/mL
(Apo E, Complement C3)
standard curve range: 0.3-1,000 ng/mL
(Complement Factor H)
standard curve range: 0.5-2,000 ng/mL
(α-2-Macroglobulin)
standard curve range: 0.7-3,000 ng/mL
(Apo A1)

técnica(s)

multiplexing: suitable

método de detecção

fluorometric (Luminex xMAP)

Condições de expedição

wet ice

Descrição geral

Neurodegenerative disease is a condition characterized by the deterioration of neurons or their myelin sheath over time in the brain and/or spinal cord. These neurons are responsible for such everyday activities as processing sensory information, making decisions, and controlling movement. Because these cells are not easily regenerated, excessive cumulative damage can lead to age-related diseases such as Alzheimer′s and Parkinson′s disease, as well as other conditions such as amyotrophic lateral sclerosis (ALS) and epilepsy. These disorders are devastating and expensive, both on a personal and global level, and as population demographics continue to change, a therapeutic solution is critical. Consequently, research is underway to identify biomarkers that will help scientists not only understand the pathogenesis of neurodegenerative disease, but also identify people with these disorders before the onset of symptoms and potentially provide new therapeutic tools.
The “MILLIPLEX” Human Neurodegenerative Bead Panel 1 (HNDG1MAG-36K) is to be used for the simultaneous quantification of the following 7 analytes in any combination: α-2-Macroglobulin, Apo A1, Apo CIII, Apo E, Complement C3 and Complement Factor H. This kit may be used for the analysis of all above analytes in human serum, plasma, and cerebrospinal fluid samples.

Panel Type: Neuroscience

Especificidade

Cross Reactivty
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Aplicação

  • Analytes: : α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3, Complement Factor H
  • Recommended Sample type: serum, plasma and CSF
  • Recommended Sample dilution: 1:40,000 diluted serum/plasma or 1:400 diluted CSF per well
  • Assay Run Time: One day
  • Research Category: Neuroscience

Características e benefícios

Design your multiplex kit by choosing available analytes within this panel.

Embalagem

Everything you need in a single kit.

Armazenamento e estabilidade

Recommended storage for kit components is 2 - 8°C.

Outras notas

Sensitivity: See protocol for sensitivities of individual analytes

Informações legais

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Órgãos-alvo

Respiratory Tract

Código de classe de armazenamento

10 - Combustible liquids

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Cerebrospinal fluid complement activation in patients with pneumococcal and meningococcal meningitis.
Mook-Kanamori, BB; Brouwer, MC; Geldhoff, M; Ende, Av; van de Beek, D
The Journal of Infection null
William T Hu et al.
Acta neuropathologica communications, 4, 14-14 (2016-02-19)
CSF levels of established Alzheimer's disease (AD) biomarkers remain stable despite disease progression, and non-amyloid non-tau biomarkers have the potential of informing disease stage and progression. We previously identified complement 3 (C3) to be decreased in AD dementia, but this
Abdul Hye et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 10(6), 799-807 (2014-07-12)
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Three multicenter cohorts of cognitively healthy

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