GR11L
Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)
lyophilized, clone αIR3, Calbiochem®
Sinônimo(s):
Anti-IGF-IR, Anti-Insulin-Like Growth Factor Receptor, Anti-Insulin-Like Growth Factor Receptor, Anti-IGF-IR
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
αIR3, monoclonal
Formulário
lyophilized
não contém
preservative
reatividade de espécies
human
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
Isotipo
IgG1
Condições de expedição
ambient
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... IGF1R(3480)
Descrição geral
This Anti-IGF-IR (Ab-1) Mouse mAb (αIR3) is validated for use in IF, IP, Neutralization Studies, Paraffin Sections, Immunoblotting for the detection of IGF-IR (Ab-1).
Aplicação
Immunofluorescence (1-5 µg/ml)
Immunoprecipitation (1 µg/sample)
Neutralization Studies (1 µg/ml; see application references)
Paraffin Sections (not recommended)
Immunoblotting (not recommended)
Immunoprecipitation (1 µg/sample)
Neutralization Studies (1 µg/ml; see application references)
Paraffin Sections (not recommended)
Immunoblotting (not recommended)
Advertência
Toxicity: Standard Handling (A)
forma física
Lyophilized from 20 mM ammonium bicarbonate solution, 100 µg BSA .
Reconstituição
Reconstitute with sterile phosphate buffered saline (PBS), pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to a final concentration of 100 µg/ml. Lyophilized antibodies should be resuspended at 4°C with occasional gentle mixing for at least two h. Following reconstitution, aliquot and freeze (-20°C) or refrigerate (4°C) with 0.1% sodium azide. Freezing of aliquots is recommended for long term storage of reconstituted product. Avoid freeze/thaw cycles of solutions.
Outras notas
Blocks IGF-I binding to the IGF-I receptor. May also weakly cross-react with the insulin receptor (see application references). It also inhibits the growth of MCF-7 cells in culture suggesting the IGF-I receptor may be involved in autocrine regulation of cell growth (see application references). Antibody should be titrated for optimal results in individual systems.
Roth, R. 1988. Science239, 1269.
Rohlik, Q.T., et al. 1987. Biochem. Biophy Res. Comm.149, 276.
Rosen, O.M. 1987. Science257, 1452.
Rechler, M.M., and Nissley, S.P. 1986. Hormone Res.24, 152.
Ullrich, A., et al. 1986. EMBO J.5, 2503.
Zapf, S., and Froesch, E.R. 1986. Hormone Res.24, 121.
Humbel, R.E. 1984. I. Chemistry in Li Hormonal proteins and peptides. Vol 12, Chap. 4 (Academic Press, New York, 1984).
Kull, F.C., et al.1983. J. Biol. Chem.258, 6561.
Rohlik, Q.T., et al. 1987. Biochem. Biophy Res. Comm.149, 276.
Rosen, O.M. 1987. Science257, 1452.
Rechler, M.M., and Nissley, S.P. 1986. Hormone Res.24, 152.
Ullrich, A., et al. 1986. EMBO J.5, 2503.
Zapf, S., and Froesch, E.R. 1986. Hormone Res.24, 121.
Humbel, R.E. 1984. I. Chemistry in Li Hormonal proteins and peptides. Vol 12, Chap. 4 (Academic Press, New York, 1984).
Kull, F.C., et al.1983. J. Biol. Chem.258, 6561.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Katrin Friedbichler et al.
Molecular cancer therapeutics, 13(2), 399-409 (2013-12-04)
Insulin-like growth factor (IGF) signaling is thought to play a role in the development and progression of multiple cancer types. To date, therapeutic strategies aimed at disrupting IGF signaling have largely focused on antibodies that target the IGF-I receptor (IGF-IR).
C Meier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(10), 3847-3859 (1999-05-11)
Although Schwann cell precursors from early embryonic nerves die in the absence of axonal signals, Schwann cells in older nerves can survive in the absence of axons in the distal stump of transected nerves. This is crucially important, because successful
Daniela Kiepe et al.
Endocrinology, 149(10), 4901-4911 (2008-06-17)
The IGF/IGF binding protein (IGFBP) system is an important component in the hormonal regulation of longitudinal growth. Evidence from in vitro studies indicates that IGFBPs may have IGF-independent effects. We analyzed the biological activity of intact IGFBP-2 and defined carboxy-terminal
Alexis R Demonbreun et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(4), 1284-1295 (2009-12-17)
Insulin-like growth factor (IGF) is a potent stimulus of muscle growth. Myoferlin is a membrane-associated protein important for muscle development and regeneration. Myoferlin-null mice have smaller muscles and defective myoblast fusion. To understand the mechanism by which myoferlin loss retards
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