ABS192

Anti-phospho-SRPK2 (Ser497) Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): SRSF protein kinase 2, SFRS protein kinase 2, Serine/arginine-rich protein-specific kinase 2, SR-protein-specific kinase 2, SRSF protein kinase 2 N-terminal, SRSF protein kinase 2 C-terminal
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: hamster, mouse, human
• reatividade da espécie (prevista por homologia): rat (based on 100% sequence homology), Xenopus (based on 100% sequence homology)
• técnica(s): western blot: suitable
• nº de adesão NCBI: NP_872633
• nº de adesão UniProt: P78362
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: phosphorylation (pSer497)
• Informações sobre genes: human ... SRPK2(6733)

Descrição

Descrição geral

SRPK2 is also known as SRSF protein kinase 2, SFRS protein kinase 2, and Serine/arginine-rich protein-specific kinase 2. SRPK2 is a kinase which is involved in the phosphorylation of SR splicing factors, and the regulation of splicing. SRPK2 also promotes neuronal apoptosis, plays an essential role in splicesomal B complex formation, and mediates hepatitis B virus (HBV) replication and core protein phosphorylation. SRPK2 is highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.

Especificidade

This antibody recognizes the protein kinase domain of SRPK2 phosphorylated at Ser497.

Imunogênio

Epitope: Protein kinase domain

KLH-conjugated linear peptide corresponding to the protein kinase domain of human SRPK2 (Ser497).

Aplicação

Anti-phospho-SRPK2 (Ser497) Antibody is a highly specific rabbit polyclonal antibody, that targets SRPK & has been tested in western blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Qualidade

Evaluated by Western Blotting in NIH3T3 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SRPK2 (Ser497) in 10 µg of NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate.

Descrição-alvo

~120 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~77 kDa and ~79 kDa Uniprot states 8 phosphorylation sites are known to exist.

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable