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Merck
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Documentos Principais

ABF212

Sigma-Aldrich

Anti-CIITA Antibody

from rabbit, purified by affinity chromatography

Sinônimo(s):

MHC class II transactivator, MHC2TA, C2TA, NLRA, CIITAIV

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

mouse, human

técnica(s)

immunohistochemistry: suitable
western blot: suitable

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CIITA(4261)

Descrição geral

CIITA, also known as MHC class II transactivator (MHC2TA), is located in the nucleus and is an essential factor for transcriptional activity of the HLA class II promoter. CIITA is suggested to be a positive regulator of class II major histocompatibility complex gene transcription and is referred to as the "master control factor" for the expression of these genes. Additionally, CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. CIITA binds with GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind with DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Furthermore, it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. CIITA has been shown to interact with ZXDA and ZXDC. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

Imunogênio

KLH-conjugated linear peptide corresponding to human CIITA.

Aplicação

Detect MHC class II transactivator using this rabbit polyclonal antibody, Anti-CIITA Antibody validated for use in western blotting & IHC.
Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected CIITA in human brain tissue.
Research Category
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms

Qualidade

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected CIITA in 15 µg of mouse brain tissue lysate.

Descrição-alvo

~122 kDa observed. Uncharacterized bands may appear in some lysate(s).

forma física

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Mouse brain tissue lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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