AB5060
Anti-Substance P Receptor Antibody, pain
serum, Chemicon®
Sinônimo(s):
NK-1 Receptor
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
serum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
rat, guinea pig, mouse
fabricante/nome comercial
Chemicon®
técnica(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... TAC1(6863)
Descrição geral
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Especificidade
Specific for the Substance P Receptor (NK-1).
Imunogênio
Epitope: C terminus
Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
Aplicação
Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
Qualidade
Evaluated by western blot on Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Descrição-alvo
35 kDa
Ligação
Replaces: AB5800
forma física
Rabbit polyclonal serum containing no preservative.
Unpurified
Armazenamento e estabilidade
Stable for 1 year at -20ºC from date of receipt.
Nota de análise
Control
Spinal Cord, brain membrane lysate
Spinal Cord, brain membrane lysate
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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recomendado
Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Mantyh, P W, et al.
Science (New York, N.Y.), 278, 275-279 (1997)
Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells.
Vigna, S R, et al.
The Journal of Neuroscience, 14, 834-845 (1994)
A R Castro et al.
Neuroscience, 141(4), 2087-2095 (2006-07-01)
Secondary hyperalgesia in the monoarthritic rat is accompanied by a decrease in nociceptive activation of spinal neurons expressing GABA(B) receptors and by the opposite effect in the cells expressing neurokinin 1 (NK1)-receptors. In order to ascertain the relative role of
Postsynaptic dorsal column neurons express NK1 receptors following colon inflammation.
J Palecek, V Paleckova, W D Willis
Neuroscience null
Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Lasztoczi, B; Tukker, JJ; Somogyi, P; Klausberger, T
The Journal of Neuroscience null
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