AB5058
Anti-Prion Protein Antibody, NT, a.a. 78-97
serum, Chemicon®
Sinônimo(s):
PrP, CD230
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.43
Produtos recomendados
fonte biológica
goat
Nível de qualidade
forma do anticorpo
serum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
human
fabricante/nome comercial
Chemicon®
técnica(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... PRNP(5621)
Especificidade
Specific for human prion protein (PrP). This antibody immunolabels amyloid plaques in formalin-fixed paraffin sections from Creutzfeld-Jakob Disease (CJD) brain.The prion protein is a large membrane protein that occurs normally in neurons of the human brain and is thought to be involved in synaptic transmission. In prion diseases, such as CJD, Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered protein when it comes into contact with an infectious prion protein (PrPsc) from another host. This altered PrPsc accumulates in cytoplasmic vesicles of diseased individuals forming lesions, vacuoles and amyloid deposits.
Imunogênio
Epitope: N-terminus, a.a. 78-97
Synthetic peptide that corresponds to amino acids 79-97 of the N-terminus of the human PrP27-30.
Aplicação
Anti-Prion Protein Antibody, N-terminus, a.a. 78-97 detects level of Prion Protein & has been published & validated for use in ELISA, WB, IH(P).
Immunohistochemistry: >1:200 on paraffin embedded, formalin fixed human brain.
Western blots: >1:2,000
ELISA: >1:35,000
Optimal working dilutions must be determined by the end user.
Western blots: >1:2,000
ELISA: >1:35,000
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
forma física
Goat serum. Liquid containing 0.01% thimerosal
Armazenamento e estabilidade
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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recomendado
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Copper has differential effect on prion protein with polymorphism of position 129.
B S Wong, C Clive, S J Haswell, R A Williamson, D R Burton, P Gambetti, M S Sy, I M Jones, D R Brown
Biochemical and biophysical research communications null
Toluidine blue-O staining of prion protein deposits.
A Sanchez, A Guzman, A Ortiz, D Rembao, B Espinosa, E Zenteno, J Guevara
Histochemistry and Cell Biology null
Selective oxidation of methionine residues in prion proteins.
B S Wong, H Wang, D R Brown, I M Jones
Biochemical and biophysical research communications null
Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse.
Adam W Hantman, Edward R Perl
The Journal of Comparative Neurology null
Creutzfeldt-Jakob disease in Mexico.
Leora Velasquez-Perez, Daniel Rembao-Bojorquez, Jorge Guevara et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology null
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