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AB1889

Sigma-Aldrich

Anti-C-C Chemokine Receptor 5 Antibody, NT

Chemicon®, from rabbit

Sinônimo(s):

CCR-5, CD195

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.43

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

técnica(s)

western blot: suitable

nº de adesão NCBI

NM_000579.3
NM_001100168.1

nº de adesão UniProt

P51681

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CCR5(1234)

Descrição geral

HIV and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G-protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (1,2). Among them, CCR5 is a principle coreceptor for macrophage- and dual-tropic HIV-1 strains fusion of entry of human white blood cells (3,4). The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

Especificidade

Specific for human C-C Chemokine Receptor 5 (CCR5) at the N-terminus.

Imunogênio

Epitope: N-terminus
Synthetic peptide from the N-terminal domain of human CCR5.

Aplicação

Anti-C-C Chemokine Receptor 5 Antibody, N-terminus is an antibody against C-C Chemokine Receptor 5 for use in WB.
Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Western blot: 1:1000 - 1:2000 (THP-1 whole cell lysate can be used as a positive control)

Optimal working dilutions must be determined by end user.

forma física

Format: Purified
Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.

Armazenamento e estabilidade

Store at 2-8°C for up to 12 months.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

T Dragic et al.
Nature, 381(6584), 667-673 (1996-06-20)
The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse
H Deng et al.
Nature, 381(6584), 661-666 (1996-06-20)
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry
Chemokine receptors: keys to AIDS pathogenesis?
D R Littman
Cell, 93(5), 677-680 (1998-06-18)
How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
D S Dimitrov
Cell, 91(6), 721-730 (1997-12-31)

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