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Merck
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Key Documents

AB1033

Sigma-Aldrich

Anti-Versican Antibody, a.a. 1360-1439 of mouse versican

Chemicon®, from rabbit

Sinônimo(s):

GAG beta Domain

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

mouse

fabricante/nome comercial

Chemicon®

técnica(s)

immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ACAN(176)

Descrição geral

Versican is a large multi-domain chondroitin sulphate proteoglycan, is secreted by fibroblasts and other types of cells. It has a N-terminal hyaluronic acid (HA) binding domain. This domain has homology with the G1 and G2 domains of aggrecan, (G1 is the hyaluronic acid binding region), to cartilage link protein which stabilizes the binding of aggrecan to hyaluronic acid, and, to the hyaluronate receptor CD44. In addition, versican also has a lectin like domain, a C-terminal compliment repeat, and two EGF-like repeats, all of which can be found in aggrecan., Versican has an apparent molecular mass of ca. 1000 kDa, of which the core contributes 400 kDa from the 2409 amino acids, and the 12 -15 covalently attached chondroitin sulphate chains make up the rest.

Especificidade

Mouse versican GAG beta domain.

Imunogênio

Epitope: a.a. 1360-1439 of mouse versican
GST fusion protein containing amino acids 1360-1439 of mouse versican.

Aplicação

Anti-Versican Antibody, a.a. 1360-1439 of mouse versican is an antibody against Versican for use in IP, WB, IH(P).
Immunohistochemistry (formally fixed, paraffin embedded): 10 μg/mL. Tissues must be treated with Chondroitinase before staining. {0.5U/mL in 100mM Tris-HCL pH 7.2-7.4, 30 minutes at room temperature} Then block and stain.

Western blotting: 0.5 μg/mL

Immunoprecipitation:

Optimal working dilutions must be determined by the end user.

forma física

Format: Purified
The immunoglobulin was affinity purified against the recombinant antigen and is presented in PBS. Anti-GST reactivity has not been adsorbed. Liquid in PBS.

Armazenamento e estabilidade

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeat freeze/thaw cycles.

Nota de análise

Control
Immunohistochemistry Positive control: surrounding cartilageWestern blotting positive control: total 13 day mouse embryo

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Design of a miniature tissue culture system to culture mouse heart valves.
Lieber SC, Kruithof BP, Aubry N, Vatner SF, Gaussin V
Annals of Biomedical Engineering null
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis.
Fu, Y; Nagy, JA; Brown, LF; Shih, SC; Johnson, PY; Chan, CK; Dvorak, HF; Wight, TN
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society null
Fabienne Meier-Abt et al.
Breast cancer research : BCR, 15(2), R36-R36 (2013-04-30)
Early pregnancy has a strong protective effect against breast cancer in humans and rodents, but the underlying mechanism is unknown. Because breast cancers are thought to arise from specific cell subpopulations of mammary epithelia, we studied the effect of parity
Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development.
Huang, F; Thompson, JC; Wilson, PG; Aung, HH; Rutledge, JC; Tannock, LR
Journal of Lipid Research null
Early but not late pregnancy induces lifelong reductions in the proportion of mammary progesterone sensing cells and epithelial Wnt signaling.
Meier-Abt, F; Brinkhaus, H; Bentires-Alj, M
Breast Cancer Research null

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