8.53075

Boc-Gln(Trt)-OH

Novabiochem^®

• Sinônimo(s): Boc-Gln(Trt)-OH, N-α-t.-Boc-γ-trityl-L-glutamine
• Fórmula empírica (Notação de Hill): C₂₉H₃₂N₂O₅
• Número CAS: 132388-69-3
• Peso molecular: 488.57
• Número MDL: MFCD00153305
• Código UNSPSC: 12352209
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• linha de produto: Novabiochem^®
• Ensaio: ≥98% (TLC)
• Formulário: powder
• adequação da reação: reaction type: Boc solid-phase peptide synthesis
• fabricante/nome comercial: Novabiochem^®
• aplicação(ões): peptide synthesis
• grupo funcional: amide
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: N([C@@H](CCC(=O)NC(c3ccccc3)(c2ccccc2)c1ccccc1)C(=O)O)C(=O)OC(C)(C)C
• InChI: 1S/C29H32N2O5/c1-28(2,3)36-27(35)30-24(26(33)34)19-20-25(32)31-29(21-13-7-4-8-14-21,22-15-9-5-10-16-22)23-17-11-6-12-18-23/h4-18,24H,19-20H2,1-3H3,(H,30,35)(H,31,32)(H,33,34)/t24-/m0/s1
• chave InChI: YEXNCDUSVVLUFM-DEOSSOPVSA-N

Descrição

Descrição geral

A trityl-protected derivative which increases the solubility of glutamine during the coupling step in SPPS ^[1]. Its use gives higher yields and lower by-product formation. During the following coupling cycles the temporary side-chain protection is removed.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

^[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.

Ligação

Replaces: 04-12-0188

Nota de análise

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -3.0 - -2.0 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable