616464
SB431542
≥97% (HPLC), liquid, TGF-β RI kinase inhibitor, Calbiochem®
Sinônimo(s):
InSolution TGF-β RI Kinase Inhibitor VI, SB431542
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About This Item
Fórmula empírica (Notação de Hill):
C22H16N4O3 · 2H2O
Número CAS:
Peso molecular:
420.42
Código UNSPSC:
51111800
NACRES:
NA.77
Produtos recomendados
product name
TGF-β RI Kinase Inhibitor VI, SB431542, InSolution, ≥97%
Nível de qualidade
Ensaio
≥97% (HPLC)
forma
liquid
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
desiccated (hygroscopic)
protect from light
Condições de expedição
ambient
temperatura de armazenamento
−20°C
InChI
1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
chave InChI
FHYUGAJXYORMHI-UHFFFAOYSA-N
Descrição geral
A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).
Embalagem
Packaged under inert gas
Advertência
Toxicity: Irritant (B)
forma física
A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO.
Reconstituição
Following initial thaw, aliquot and freeze (-20°C).
Outras notas
Ikushima, H., et al. 2009. Cell Stem Cell5, 504.
Lin, T., et al. 2009. Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009. Curr. Biol.19, 1718.
Callahan, J.F., et al. 2002. J. Med. Chem.45, 999.
Inman, G.J., et al. 2002. Mol. Pharmacol.62, 65.
Laping, N.J., et al. 2002. Mol. Pharmacol.62, 58.
Lin, T., et al. 2009. Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009. Curr. Biol.19, 1718.
Callahan, J.F., et al. 2002. J. Med. Chem.45, 999.
Inman, G.J., et al. 2002. Mol. Pharmacol.62, 65.
Laping, N.J., et al. 2002. Mol. Pharmacol.62, 58.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
188.6 °F - (refers to pure substance)
Ponto de fulgor (°C)
87 °C - (refers to pure substance)
Certificados de análise (COA)
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