580560

TCEP, Hydrochloride

A water-soluble and odorless disulfide-reducing agent that is more stable and effective than DTT.

• Sinônimo(s): TCEP, Hydrochloride, tris(2-Carboxyethyl)phosphine, HCl
• Fórmula empírica (Notação de Hill): C₉H₁₅O₆P · xHCl
• Número CAS: 51805-45-9
• Peso molecular: 250.19 (free base basis)
• Número MDL: MFCD00145469
• Código UNSPSC: 12352128
• NACRES: NA.25

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (elemental analysis)
• Formulário: crystalline solid
• adequação da reação: reagent type: reductant
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated
• cor: white
• solubilidade: water: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C9H15O6P/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15/h1-6H2,(H,10,11)(H,12,13)(H,14,15)/p-3
• chave InChI: PZBFGYYEXUXCOF-UHFFFAOYSA-K

Descrição

Descrição geral

A water-soluble and odorless disulfide reducing agent which is more stable and effective than DTT. TCEP reduces even the most stable water-soluble alkyl disulfides at pH 4.5 within 5 min. TCEP is also capable of functioning as a reducing agent even in pH range of 1.5-8.5. Is more resistant to air-oxidation as compared to DTT.

Aplicação

• Peptide and Protein Desulfurization with Diboron Reagents.: This study investigates the use of TCEP hydrochloride in peptide and protein desulfurization, demonstrating its effectiveness in facilitating diboron-mediated reactions. (Jing & Walczak, 2024).


• A Study on Thiol-Michael Addition to Semi-Synthetic Elastin-Hyaluronan Material for Electrospun Scaffolds.: TCEP hydrochloride is utilized to enhance the thiol-Michael addition reaction in the development of electrospun scaffolds, contributing to advanced biomaterials research. (Laezza et al., 2024).


• Optimized total RNA isolation from bovine sperm with enhanced sperm head lysis.: This paper presents an optimized protocol for RNA isolation from bovine sperm, highlighting the role of TCEP hydrochloride in improving sperm head lysis efficiency. (Tiwari et al., 2024).


• Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers.: The study uses TCEP hydrochloride in a novel peroxidase-mimicking system to differentiate cystine enantiomers, showcasing its application in chiral analysis. (Xu et al., 2023).


• In situ digestion of alcohol-fixed cells for quantitative proteomics.: TCEP hydrochloride is applied in the in situ digestion of fixed cells to enhance the accuracy of quantitative proteomics analyses. (Hatano et al., 2023).

Embalagem

Packaged under inert gas

Advertência

Toxicity: Corrosive (L)

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS05
• Palavra indicadora: Danger
• Frases de perigo: H314
• Declarações de precaução: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classificações de perigo: Eye Dam. 1 - Skin Corr. 1B
• Código de classe de armazenamento: 8A - Combustible corrosive hazardous materials
• Classe de risco de água (WGK): WGK 1