565750

γ-Secretase Inhibitor I

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinônimo(s): γ-Secretase Inhibitor I, Z-LLNle-CHO
• Fórmula empírica (Notação de Hill): C₂₆H₄₁N₃O₅
• Peso molecular: 475.62
• Código UNSPSC: 12352200
• NACRES: NA.54

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: DMSO: 10 mg/mL; 50% acetic acid: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.

Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Sequência

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable