528240

Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets

• Código UNSPSC: 12352202
• NACRES: NA.25

Propriedades

• forma: liquid
• Nível de qualidade: 100
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• Condições de expedição: wet ice
• temperatura de armazenamento: −70°C

Descrição

Descrição geral

Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.

Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.

Embalagem

Please refer to vial label for lot-specific concentration.

Advertência

Toxicity: Standard Handling (A)

forma física

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, ≤0.1% sodium azide, pH 7.4.

Nota de preparo

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstituição

Following initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.

Outras notas

Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002.
Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1