5.08225

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), liquid, estrogen receptor modulator, Calbiochem

• Sinônimo(s): InSolution Tamoxifen, 4-Hydroxy-, ( Z)-, ( Z)-4-(1-(4-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol, ( Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, (Z)-4-Hydroxytamoxifen, (Z)-4-OH-TAM, trans-4-Hydroxytamoxifen
• Fórmula empírica (Notação de Hill): C₂₆H₂₉NO₂
• Número CAS: 68047-06-3
• Peso molecular: 387.51
• Número MDL: MFCD00278780
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• product name: (Z)-4-Hydroxytamoxifen, InSolution, ≥99%
• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• forma: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• temperatura de armazenamento: −70°C
• InChI: 1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
• chave InChI: DODQJNMQWMSYGS-QPLCGJKRSA-N

Descrição

Descrição geral

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Estrogen receptor

Advertência

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

forma física

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen (Cat. No. 579002) in EtOH.

Reconstituição

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.

Outras notas

Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS07,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H225 - H319 - H350 - H360FD - H412
• Declarações de precaução: P202 - P210 - P233 - P273 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Aquatic Chronic 3 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 55.4 °F
• Ponto de fulgor (°C): 13 °C