345888

JMV 2959

≥97% (HPLC), powder, Ghrelin receptor antagonist, Calbiochem^®

• Sinônimo(s): Ghrelin Receptor Antagonist, JMV 2959, Growth hormone secretagogue receptor antagonist, (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959
• Fórmula empírica (Notação de Hill): C₃₀H₃₂N₆O₂ · xHCl
• Peso molecular: 508.61 (free base basis)
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: Ghrelin Receptor Antagonist, JMV 2959,
• Ensaio: ≥97% (HPLC)
• Nível de qualidade: 100
• Formulário: powder
• potência: 32 nM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: beige
• solubilidade: DMSO: 100 mg/mL; water: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

JMV 2959, which blocks the signaling of the growth hormone secretagogue receptor 1A, reduces the deficits in prepulse inhibition induced by the NMDAR antagonist, phencyclidine.

Aplicação

Ghrelin Receptor Antagonist, JMV 2959 has been used to examine oxytocin receptor (OTR) and ghrelin receptor (GHSR) signaling. It has also been used as a GHS-R1a receptor antagonist to pretreat Hek cells followed by pyridone 8 exposure to study its effect on GHS-R1a receptor-mediated calcium influx.

Ações bioquímicas/fisiológicas

Primary Target
Ghrelin receptor

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

forma física

Supplied as a hydrochloride salt.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Moulin, A., et al. 2013. Amino Acids44, 301.
Mary, S., et al. 2012. Proc Natl Acad Sci USA109, 8304.
Salome, N., et al. 2009. Eur J Pharmacol.612, 167,.
Moulin, A., et al. 2007. J Med Chem50, 579.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable