344847

Fumitremorgin C

from Aspergillus. fumigatus, ≥95% (HPLC), lyophilized, BCRP/ABCG2 inhibitor, Calbiochem^®

• Sinônimo(s): Fumitremorgin C, Aspergillus. fumigatus, NSC719655, FTC
• Fórmula empírica (Notação de Hill): C₂₂H₂₅N₃O₃
• Número CAS: 118974-02-0
• Peso molecular: 379.45
• Número MDL: MFCD08702652
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: Fumitremorgin C, Aspergillus. fumigatus, A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity.
• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: lyophilized
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• solubilidade: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1
• chave InChI: DBEYVIGIPJSTOR-FHWLQOOXSA-N

Descrição

Descrição geral

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Toxic (F)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111.
Rabindran, S.K., et al. 2000. Cancer Res.60, 47.
Rabindran, S.K., et al. 1998. Cancer Res.58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable