341280

Factor I, Human

Factor I, Human, is a glycoprotein composed of two non-identical disulfide-bonded subunits of 50 and 38 kDa. A serine protease that requires protein cofactor in order to effect substrate cleavage.

• Sinônimo(s): C3b/C4b Inactivator
• Código UNSPSC: 12352202
• NACRES: NA.25

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (SDS-PAGE)
• Formulário: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; avoid repeated freeze/thaw cycles
• Impurezas: IgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin, trace
• Condições de expedição: wet ice
• temperatura de armazenamento: −70°C

Descrição

Descrição geral

Native factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of 50 kDa (α) and 38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Thus, either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I-mediated cleavage of C4b.

Embalagem

Please refer to vial label for lot-specific concentration.

Advertência

Toxicity: Standard Handling (A)

forma física

In PBS, pH 7.2.

Nota de preparo

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstituição

Following initial thaw, aliquot and freeze (-70°C).

Outras notas

Solol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable