215901

Carbonic Anhydrase IX/XII Inhibitor II, U-104

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinônimo(s): Carbonic Anhydrase IX/XII Inhibitor II, U-104, CAIX Inhibitor II
• Fórmula empírica (Notação de Hill): C₁₃H₁₂FN₃O₃S
• Peso molecular: 309.32
• Número MDL: MFCD00159265
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Fc1ccc(cc1)NC(=O)Nc2ccc(cc2)[S](=O)(=O)N
• chave InChI: YJQZNWPYLCNRLP-UHFFFAOYSA-N

Descrição

Descrição geral

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4^Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Regulatory Review (Z)

Outras notas

Lock, F.E., et al. 2012. Oncogenein press.
Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable