203694

bpV(bipy)

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation).

• Sinônimo(s): bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
• Fórmula linear: K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (⁵¹V-NMR)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow to orange
• solubilidade: water: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

A potent inhibitor of phosphotyrosine phosphatase activity (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
phosphotyrosine phosphatase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 18 nM against PTEN

Target K_i: 100 nM for phosphotyrosine phosphatase

Embalagem

Packaged under inert gas

Advertência

Toxicity: Harmful (C)

Reconstituição

Unstable in solution; reconstitute just prior to use.

Outras notas

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable