14-902-M

AMPK (α2, β1, γ1) Protein, active, 10 µg

Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propriedades

• fonte biológica: human
• Nível de qualidade: 100
• recombinante: expressed in E. coli
• linha de produto: Upstate^®
• atividade específica: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• peso molecular: M_w 30 kDa (AMPKß1); M_w 38 kDa (AMPKγ1); M_w 63 kDa (AMPKα2)
• purificado por: (Ni²⁺/NTA-agarose)
• reatividade de espécies: human
• fabricante/nome comercial: Upstate^®
• técnica(s): activity assay: suitable (kinase)
• nº de adesão: (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ); NM_006252
• nº de adesão NCBI: NM_002733; NM_006252; NM_006253
• nº de adesão UniProt: P54619; P54646; P54646, Q9Y478, P54619; Q9Y478
• doença(s) relevante(s): diabetes; obesity; metabolic disorders
• Informações sobre genes: human ... PRKAA2(5563) , PRKAB1(5563)

Descrição

Descrição geral

Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.

Aplicação

Research Category
Metabolism

Apoptosis & Cancer

Research Sub Category
Diabetes

Obesity

Metabolic Disorders

Ações bioquímicas/fisiológicas

Protein Target: AMPK (α2, β1, γ1)

Target Sub-Family: CAMK

Embalagem

Also available in 10 μg size and in bulk

Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.

Qualidade

Routinely evaluated by phosphorylation of substrate peptide

Descrição-alvo

AMPK (α2, β1, γ1)

forma física

Cobalt-agarose

Armazenamento e estabilidade

6 months at -70°C

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317
• Declarações de precaução: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classificações de perigo: Skin Sens. 1
• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°C): Not applicable