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Documentos Principais

14-439-M

Sigma-Aldrich

MAP Kinase 1/Erk1 Protein, active, 10 µg

Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.

Sinônimo(s):

ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK

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About This Item

Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32

fonte biológica

human

Nível de qualidade

100

recombinante

expressed in E. coli

Formulário

liquid

peso molecular

Mw 69.9 kDa

fabricante/nome comercial

Upstate®

técnica(s)

activity assay: suitable (kinase)

cor

colorless

solubilidade

water: soluble

nº de adesão NCBI

NM_002745.4
NM_138957.3

nº de adesão UniProt

P28482

Informações sobre genes

human ... MAPK3(5595)

Descrição geral

Research area: Cell Signaling

Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag

Ações bioquímicas/fisiológicas

Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.

Embalagem

Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.

Qualidade

routinely evaluated by phosphorylation of MBP

forma física

Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)

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