1.04672

Colesterol

EMPROVE^® EXPERT, Ph. Eur., BP, JP, NF

• Sinônimo(s): 3β-Hidroxi-5-colesteno, 5-Colesteno-3β-ol
• Fórmula empírica (Notação de Hill): C₂₇H₄₆O
• Número CAS: 57-88-5
• Peso molecular: 386.65
• Beilstein: 1915888
• Número MDL: MFCD00003646
• Código UNSPSC: 12352104

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 500
• Agency: BP; JP; NF; Ph. Eur.
• linha de produto: EMPROVE^® EXPERT
• forma: powder
• pb: 360 °C (lit.)
• pf: ~141 °C; 147-149 °C (lit.)
• densidade: 1.067 g/mL at 25 °C (lit.)
• adequação: suitable for (Suitable for formulation and manufacturing use)
• aplicação(ões): advanced drug delivery; controlled release; liquid formulation; parenterals; pharmaceutical
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• chave InChI: HVYWMOMLDIMFJA-DPAQBDIFSA-N

Descrição

Descrição geral

A GMP-scalable process which yields a high-quality lipid is essential to lipidic drug product development and manufacturing. We are highly specialized in synthesizing top-quality GMP lipids for pharmaceutical applications and gene therapy, focusing on tailored manufacturing to meet your specific needs. We also offer an off-the-shelf catalog with optimized stability, solubility, and handling characteristics.
Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Cholesterol is a major component of all biological cell membranes and is used as a stabilizer of lipid bilayers in many lipid-based formulations for the delivery of different APIs, such as small molecules and nucleic acids.
Synthetic cholesterol, Ph Eur, BP, JP, NF is ultra-pure and therefore suitable for divers formulations applications. Due to low batch to batch variability, very high purity, and lack of biological components, this product is optimal for highly sensitive applications such as nucleic acid delivery.
With a newly optimized manufacturing process, this product is available in quantities from grams to tons to support your development progress. A dual sourcing option is also possible.

Ações bioquímicas/fisiológicas

Componente importante de todas as membranas biológicas; cerca de 25% do teor total de lipídios no cérebro é de colesterol.

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

SyntheChol is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

The substance 1.04672 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable