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Documentos Principais

09-126

Sigma-Aldrich

Anti-Tribbles-1 Antibody

Upstate®, from rabbit

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

human

fabricante/nome comercial

Upstate®

técnica(s)

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG

nº de adesão NCBI

NP_079471

nº de adesão UniProt

Q96RU8

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... TRIB1(10221)

Descrição geral

The Tribbles family of proteins are kinase-like proteins that contain a kinase-like domain, but lack either a catalytic domain or a protein-protein interaction domain (2). They are believed to regulate signal processing for various pathways including MAPK, Akt, and NFkB that are involved in various aspects of development, diabetes, and cancer (1,2,3). Their involvement has been reported to regulate a number of pathways that include mitosis, cell activation, and apoptosis. They are are a family made up of three family members. Tribbles-1 (TRIB1, SKIP1, G-protein-coupled receptor induced protein, and phosphoprotein regulated by mitogenic pathways) is a modulator of MAPK action. It has been shown to directly interact with the upstream kinases MEK1 and MKK4 of Erk and JNK, respectively(1). Tribble-2 (Trib2, TRB2) has been shown to interact with Akt(2). Tribbles-3 (TRIB3, TRB3. NIPK, SKIP3) has been shown to interact with Akt and the transcription factors ATF4 and NFkB p65 (RelA). It is interaction with RelA is thought to be negative regulation. Interestingly, it has been reported to regulate Akt activation via insulin(3).

Especificidade

Tribbles-1

Imunogênio

KLH-conjugated sythetic linear peptide directed against a region of the N-terminal portion of Tribbles-1.

Aplicação

This Anti-Tribbles-1 Antibody is validated for use in IH, WB for the detection of Tribbles-1.

Qualidade

routinely evaluated by western blot on lysate from HeLa cells

Descrição-alvo

41 kDa

forma física

100 μg in 100μL of affinity purified rabbit serum in storage buffer containing PBS with 0.05% sodium azide.

Nota de análise

Control
HeLa

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Hye Youn Sung et al.
Biology, 1(1), 43-57 (2012-01-01)
Development of the atherosclerotic plaque involves a complex interplay between a number of cell types and an extensive inter-cellular communication via cell bound as well as soluble mediators. The family of tribbles proteins has recently been identified as novel controllers
Jessica M Johnston et al.
Science advances, 5(10), eaax9183-eaax9183 (2019-11-07)
Macrophages drive atherosclerotic plaque progression and rupture; hence, attenuating their atherosclerosis-inducing properties holds promise for reducing coronary heart disease (CHD). Recent studies in mouse models have demonstrated that Tribbles 1 (Trib1) regulates macrophage phenotype and shows that Trib1 deficiency increases

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