07-1548

Anti-HDAC11 Antibody

from rabbit

• Sinônimo(s): histone deacetylase 11
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: purified antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• reatividade de espécies: human, mouse
• técnica(s): ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• nº de adesão NCBI: NP_079103
• nº de adesão UniProt: Q96DB2
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... HDAC11(79885) ; mouse ... Hdac11(232232)

Descrição

Descrição geral

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Especificidade

Not tested in other species.

This antibody recognizes HDAC11.

Imunogênio

Epitope: N-terminus

The immunogen was a KLH-conjugated synthetic peptide corresponding the N-terminal region of human HDAC11.

Aplicação

ELISA:
This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).

Immunohistochemistry:
This antibody has been shown by an outside laboratory to be suitable for histochemistry using formalin fixed, paraffin embedded human hepatocarcinoma tissue (1:50-1:100).

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Use Anti-HDAC11 Antibody (Rabbit Polyclonal Antibody) validated in WB, ELISA, IHC to detect HDAC11 also known as histone deacetylase 11.

Qualidade

Western Blot Analysis:
Detection of HDAC11 in 10 µg of Mouse Brain lysate by Western blot analysis.

Descrição-alvo

~40 kDa

forma física

Format: Purified

Protein G Chromatography

Purified rabbit polyclonal in buffer containing 0.09% NaN3.

Armazenamento e estabilidade

Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Nota de análise

Control
Mouse Brain cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable