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T-068

Supelco

Tilidine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (Notação de Hill):
C17H23NO2 · HCl
Número CAS:
27107-79-5
Peso molecular:
309.83
Número CE:
200-659-6
Número MDL:
MFCD01735084
Código UNSPSC:
41116107
ID de substância PubChem:
329826611
NACRES:
NA.24

grau

certified reference material

forma

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentração

1.0 mg/mL in methanol (as free base)

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

forensics and toxicology

formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)c2ccccc2

InChI

1S/C17H23NO2.ClH/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3;/h5-8,10-12,15H,4,9,13H2,1-3H3;1H/t15-,17+;/m1./s1

chave InChI

MUWDJVKYGSDUSH-KALLACGZSA-N

Categorias relacionadas

Descrição geral

Tilidine is a synthetic opioid analgesic used mainly in Germany, Switzerland and Belgium for treatment of moderate to severe pain, both acute and chronic. While tilidine is considered a moderately-potent opioid, its active metabolite nortilidine possesses analgesic effects roughly equivalent to that of morphine.

Aplicação

  • Opioid Detection in Hair: Research demonstrated the application of liquid chromatography/tandem mass spectrometry for detecting opioids, including Tilidine, in hair samples from palliative care patients, offering insights into long-term drug use and compliance monitoring (Musshoff et al., 2007).

  • Drug Testing in Hair Analysis: An analytical technique using LC-ESI-MS/MS and MALDI-MS/MS imaging was utilized to distinguish between Tilidine intake and external contamination in segmental hair analysis, improving accuracy in drug testing scenarios (Poetzsch et al., 2015).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Barbara Grün et al.
British journal of clinical pharmacology, 74(5), 854-863 (2012-03-03)
The analgesic activity of tilidine is mediated by its active metabolite, nortilidine, which easily penetrates the blood-brain barrier and binds to the µ-opioid receptor as a potent agonist. Tilidine undergoes an extensive first-pass metabolism, which has been suggested to be
Isabel Wustrow et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(6), 633-639 (2012-02-22)
Tilidine exhibits the highest consumption of opioids in Germany. The prodrug is hepatically metabolised in a sequential N-demethylation reaction. Its primary metabolite nortilidine is a selective μ-opioid receptor agonist which can penetrate the blood-brain barrier. Cytochrome P450 isozymes (CYP) 3A4
[Not to change therapy unnecessarily! Step 2 opioids at first prescription are of advantage].
MMW Fortschritte der Medizin, 147(45), 63-63 (2005-12-03)
Johanna Weiss et al.
Naunyn-Schmiedeberg's archives of pharmacology, 378(3), 275-282 (2008-06-03)
Tilidine is one of the most widely used narcotics in Germany and Belgium. The compound's active metabolite nortilidine easily penetrates the blood-brain barrier and activates the mu-opioid receptor. Thus far, the enzymes involved in tilidine metabolism are unknown. Therefore, the
Paul J Fudala et al.
Drug and alcohol dependence, 83 Suppl 1, S40-S47 (2006-03-28)
Non-medical abuse of prescription opioid medications is not a new phenomenon, but such use has been increasing in recent years. Various methods have been used and continue to be developed in an effort to limit diversion and abuse of opioid
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